Clostridium difficile glutamate dehydogenase (GDH) thiab toxin A / B

Clostricium difficile (CD) yog ib qho tseem ceeb Anaerobic gram-zoo Bacillus, uas yog ib txwm muaj nyob hauv tib neeg lub cev. Lwm yam kev sib raug zoo los tiv thaiv vim yog tshuaj tua kab mob uas siv hauv cov koob tshuaj tiv thaiv loj, thiab cd reproes hauv tib neeg lub cev hauv cov khoom loj. CD tau muab faib ua cov toxin-kev tsim khoom thiab cov tsiaj uas tsis lom zem-ua yeeb yaj kiab. Txhua CD hom khoom siv glutamate dehydrogenase (gdh) thaum lawv tsim dua tshiab, thiab tsuas yog lom zem yog pathogenic. Cov kab mob toxin-tsim tau tuaj yeem tsim tau ob co toxins, thiab B. toxin A Toxin B yog lub cytotoxin, ua rau cytoskeleton, ua rau cell pyknoseton, ua rau raws plab plab, ua rau mob plab zom mov thiab pseudombranloous colitis.