Clostridium Difficile Glutamate Dehydrogenase (GDH) thiab Toxin A/B

Clostridium difficile (CD) yog ib hom kab mob anaerobic gram-positive bacillus uas tsis tas yuav kho, uas yog ib hom kab mob ib txwm muaj nyob hauv tib neeg lub cev. Lwm cov kab mob yuav raug txwv tsis pub loj hlob vim yog cov tshuaj tua kab mob siv ntau dhau, thiab CD rov tsim dua hauv tib neeg lub cev ntau heev. CD muab faib ua cov kab mob uas tsim cov tshuaj lom thiab cov kab mob uas tsis tsim cov tshuaj lom. Txhua hom CD tsim cov glutamate dehydrogenase (GDH) thaum lawv loj hlob, thiab tsuas yog cov kab mob toxigenic xwb thiaj li ua rau muaj kab mob. Cov kab mob uas tsim cov tshuaj lom tuaj yeem tsim ob hom tshuaj lom, A thiab B. Toxin A yog ib hom enterotoxin, uas tuaj yeem ua rau mob ntawm phab ntsa plab hnyuv, ua rau cov hlwb nkag mus rau hauv lub cev, ua rau cov ntshav nkag mus rau hauv cov hnyuv, thiab ua rau cov hlwb tuag. Toxin B yog ib hom cytotoxin, uas ua rau cov hlwb cytoskeleton puas tsuaj, ua rau cov hlwb pyknosis thiab necrosis, thiab ua rau cov hlwb parietal plab hnyuv puas tsuaj ncaj qha, ua rau raws plab thiab mob plab hnyuv pseudomembranous.