Clostridium Difficile Glutamate Dehydrogenase (GDH) thiab Toxin A/B

Clostridium difficile (CD) yog ib qho anaerobic gram-zoo bacillus, uas yog ib txwm muaj nyob hauv tib neeg lub cev. Lwm cov nroj tsuag yuav raug cuam tshuam los ntawm kev sib npaug vim yog cov tshuaj tua kab mob siv ntau, thiab CD rov tsim dua hauv tib neeg lub cev hauv ntau ntau. CD tau muab faib ua hom tshuaj lom thiab tsis muaj tshuaj lom. Txhua hom CD tsim glutamate dehydrogenase (GDH) thaum lawv rov tsim dua, thiab tsuas yog cov kab mob toxigenic yog cov kab mob. Toxin-produces strains tuaj yeem tsim ob co toxins, A thiab B. Toxin A yog ib qho enterotoxin, uas tuaj yeem ua rau o ntawm cov phab ntsa hauv plab hnyuv, cell infiltration, nce permeability ntawm lub plab hnyuv phab ntsa, hemorrhage thiab necrosis. Toxin B yog ib qho cytotoxin, uas ua rau lub cytoskeleton puas, ua rau cell pyknosis thiab necrosis, thiab ncaj qha ua rau cov hnyuv parietal hlwb, ua rau raws plab thiab pseudomembranous colitis.