Txhua xyoo rau lub Plaub Hlis 17th yog Hnub Mob Cancer Thoob Ntiaj Teb.
01 Kev Txheeb Xyuas Txog Kab Mob Cancer Thoob Ntiaj Teb
Nyob rau hauv xyoo tas los no, nrog rau kev nce ntxiv ntawm tib neeg lub neej thiab kev nyuaj siab ntawm lub hlwb, qhov tshwm sim ntawm cov qog nqaij hlav kuj nce ntxiv txhua xyoo.
Cov qog nqaij hlav phem (mob qog noj ntshav) tau dhau los ua ib qho teeb meem loj rau kev noj qab haus huv pej xeem uas ua rau muaj kev hem thawj rau kev noj qab haus huv ntawm cov pej xeem Suav. Raws li cov ntaub ntawv txheeb cais tshiab tshaj plaws, kev tuag ntawm cov qog nqaij hlav phem suav txog 23.91% ntawm tag nrho cov ua rau tuag ntawm cov neeg nyob hauv, thiab qhov tshwm sim thiab kev tuag ntawm cov qog nqaij hlav phem tau txuas ntxiv nce ntxiv hauv kaum xyoo dhau los. Tab sis mob qog noj ntshav tsis txhais tau tias "kev txiav txim tuag." Lub Koom Haum Kev Noj Qab Haus Huv Ntiaj Teb tau taw qhia meej meej tias tsuav yog nws raug kuaj pom thaum ntxov, 60% -90% ntawm cov qog nqaij hlav tuaj yeem kho tau! Ib feem peb ntawm cov qog nqaij hlav tuaj yeem tiv thaiv tau, ib feem peb ntawm cov qog nqaij hlav tuaj yeem kho tau, thiab ib feem peb ntawm cov qog nqaij hlav tuaj yeem kho tau kom ntev lub neej.
02 Dab tsi yog qog nqaij hlav
Qog yog hais txog cov kab mob tshiab uas tsim los ntawm kev loj hlob ntawm cov hlwb nqaij hauv zos raws li kev ua ntawm ntau yam tshuaj uas ua rau mob qog. Cov kev tshawb fawb pom tau tias cov hlwb qog hloov pauv cov metabolism txawv ntawm cov hlwb ib txwm muaj. Tib lub sijhawm, cov hlwb qog tuaj yeem hloov kho rau cov kev hloov pauv hauv qhov chaw ib puag ncig metabolic los ntawm kev hloov ntawm glycolysis thiab oxidative phosphorylation.
03 Kev Kho Mob Cancer Rau Tus Kheej
Kev kho mob qog noj ntshav rau tus kheej yog raws li cov ntaub ntawv kuaj mob ntawm cov noob caj noob ces thiab cov txiaj ntsig ntawm kev tshawb fawb kho mob raws li pov thawj. Nws muab lub hauv paus rau cov neeg mob kom tau txais txoj kev npaj kho mob kom raug, uas tau dhau los ua qhov sib txawv ntawm kev txhim kho kev kho mob niaj hnub no. Cov kev tshawb fawb hauv tsev kho mob tau lees paub tias los ntawm kev kuaj pom qhov hloov pauv ntawm cov cim qhia txog cov noob caj noob ces, hom noob caj noob ces SNP, noob caj noob ces thiab nws cov protein qhia tawm hauv cov qauv kuaj mob ntawm cov neeg mob qog noj ntshav los kwv yees qhov ua tau zoo ntawm tshuaj thiab ntsuas qhov kwv yees, thiab coj kev kho mob rau tus kheej, nws tuaj yeem txhim kho qhov ua tau zoo thiab txo cov kev tsis zoo, los txhawb kev siv cov peev txheej kho mob kom zoo.
Kev kuaj mob qog noj ntshav muaj peev xwm muab faib ua 3 hom tseem ceeb: kev kuaj mob, kev kuaj mob los ntawm noob caj ces, thiab kev kho mob. Kev kuaj mob yog lub hauv paus ntawm qhov hu ua "kev kho mob kab mob" lossis kev kho mob tus kheej, thiab ntau thiab ntau cov tshuaj tiv thaiv kab mob thiab cov tshuaj me me uas tuaj yeem tsom mus rau cov noob caj ces tseem ceeb thiab cov kev taw qhia tuaj yeem siv rau kev kho mob qog noj ntshav.
Kev kho mob qog nqaij hlav uas tsom mus rau cov molecules cim ntawm cov qog nqaij hlav thiab cuam tshuam rau hauv cov txheej txheem ntawm cov qog nqaij hlav. Nws cov nyhuv feem ntau yog rau cov qog nqaij hlav, tab sis muaj me ntsis cuam tshuam rau cov cell ib txwm. Cov receptors loj hlob ntawm qog nqaij hlav, cov molecules teeb liab, cov protein voj voog ntawm lub hlwb, cov regulators apoptosis, proteolytic enzymes, vascular endothelial growth factor, thiab lwm yam tuaj yeem siv ua cov hom phiaj molecular rau kev kho mob qog nqaij hlav. Thaum Lub Kaum Ob Hlis 28, 2020, "Kev Ntsuas Kev Tswj Xyuas rau Kev Siv Tshuaj Antineoplastic (Kev Sim)" uas tau tshaj tawm los ntawm National Health and Medical Commission tau taw qhia meej tias: Rau cov tshuaj uas muaj cov hom phiaj gene meej, lub hauv paus ntsiab lus ntawm kev siv lawv yuav tsum tau ua raws li tom qab kev kuaj gene.
04 Kev kuaj noob caj noob ces uas tsom mus rau cov qog nqaij hlav
Muaj ntau hom kev hloov pauv caj ces hauv cov qog nqaij hlav, thiab ntau hom kev hloov pauv caj ces siv cov tshuaj sib txawv. Tsuas yog los ntawm kev qhia meej txog hom kev hloov pauv caj ces thiab xaiv kev kho mob tshuaj kom raug thiaj li cov neeg mob tau txais txiaj ntsig. Cov txheej txheem kuaj mob molecular tau siv los kuaj xyuas qhov sib txawv ntawm cov noob caj ces uas cuam tshuam nrog cov tshuaj uas feem ntau tsom mus rau hauv cov qog nqaij hlav. Los ntawm kev tshuaj xyuas qhov cuam tshuam ntawm cov kev hloov pauv caj ces rau kev ua haujlwm ntawm cov tshuaj, peb tuaj yeem pab cov kws kho mob tsim cov phiaj xwm kho mob rau tus kheej tshaj plaws.
05 Kev daws teeb meem
Macro & Micro-Test tau tsim ntau yam khoom siv los nrhiav cov noob caj noob ces ntawm cov qog nqaij hlav, muab kev daws teeb meem rau kev kho mob qog nqaij hlav.
Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Tib Neeg EGFR Gene 29 (Kev siv tshuaj fluorescence PCR)
Cov khoom siv no yog siv los kuaj pom cov kev hloov pauv hauv exons 18-21 ntawm EGFR gene hauv cov qauv los ntawm cov neeg mob qog nqaij hlav hauv lub ntsws uas tsis yog me me.
1. Lub kaw lus qhia txog kev tswj xyuas zoo sab hauv, uas tuaj yeem saib xyuas cov txheej txheem sim thiab xyuas kom meej qhov zoo ntawm kev sim.
2. Kev rhiab heev: Kev kuaj pom cov tshuaj tiv thaiv nucleic acid tuaj yeem ntes tau qhov hloov pauv ntawm 1% nyob rau hauv keeb kwm yav dhau ntawm 3ng / μL hom qus.
3. Kev tshwj xeeb siab: Tsis muaj kev sib tshuam nrog cov DNA genomic tib neeg qus thiab lwm hom mutant.
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KRAS 8 Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv (Fluorescence PCR)
Cov khoom siv no yog rau kev kuaj pom qhov sib txawv ntawm 8 qhov kev hloov pauv hauv codons 12 thiab 13 ntawm K-ras gene hauv DNA rho tawm los ntawm cov seem pathological ntawm tib neeg.
1. Lub kaw lus qhia txog kev tswj xyuas zoo sab hauv, uas tuaj yeem saib xyuas cov txheej txheem sim thiab xyuas kom meej qhov zoo ntawm kev sim.
2. Kev rhiab heev: Kev kuaj pom cov tshuaj tiv thaiv nucleic acid tuaj yeem ntes tau qhov hloov pauv ntawm 1% nyob rau hauv keeb kwm yav dhau ntawm 3ng / μL hom qus.
3. Kev tshwj xeeb siab: Tsis muaj kev sib tshuam nrog cov DNA genomic tib neeg qus thiab lwm hom mutant.
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Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Tib Neeg EML4-ALK Fusion Gene (Fluorescence PCR)
Cov khoom siv no yog siv los nrhiav kom tau 12 hom kev hloov pauv ntawm EML4-ALK fusion gene hauv cov qauv ntawm cov neeg mob qog nqaij hlav hauv lub ntsws uas tsis yog me me hauv vitro.
1. Lub kaw lus qhia txog kev tswj xyuas zoo sab hauv, uas tuaj yeem saib xyuas cov txheej txheem sim thiab xyuas kom meej qhov zoo ntawm kev sim.
2. Kev rhiab heev: Cov khoom siv no tuaj yeem ntes tau kev hloov pauv fusion tsawg li 20 daim ntawv theej.
3. Kev tshwj xeeb siab: Tsis muaj kev sib tshuam nrog cov DNA genomic tib neeg qus thiab lwm hom mutant.
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Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Human ROS1 Fusion Gene (Fluorescence PCR)
Cov khoom siv no yog siv los kuaj pom 14 hom kev hloov pauv ntawm ROS1 fusion gene hauv cov qauv mob qog nqaij hlav hauv lub ntsws uas tsis yog me me.
1. Lub kaw lus qhia txog kev tswj xyuas zoo sab hauv, uas tuaj yeem saib xyuas cov txheej txheem sim thiab xyuas kom meej qhov zoo ntawm kev sim.
2. Kev rhiab heev: Cov khoom siv no tuaj yeem ntes tau kev hloov pauv fusion tsawg li 20 daim ntawv theej.
3. Kev tshwj xeeb siab: Tsis muaj kev sib tshuam nrog cov DNA genomic tib neeg qus thiab lwm hom mutant.
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Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Tib Neeg BRAF Gene V600E (Fluorescence PCR)
Cov khoom siv kuaj no yog siv los kuaj xyuas qhov kev hloov pauv ntawm BRAF gene V600E hauv cov qauv ntaub so ntswg paraffin-embedded ntawm tib neeg melanoma, mob qog nqaij hlav colorectal, mob qog nqaij hlav thyroid thiab mob qog nqaij hlav ntsws hauv vitro.
1. Lub kaw lus qhia txog kev tswj xyuas zoo sab hauv, uas tuaj yeem saib xyuas cov txheej txheem sim thiab xyuas kom meej qhov zoo ntawm kev sim.
2. Kev rhiab heev: Kev kuaj pom cov tshuaj tiv thaiv nucleic acid tuaj yeem ntes tau qhov hloov pauv ntawm 1% nyob rau hauv keeb kwm yav dhau ntawm 3ng / μL hom qus.
3. Kev tshwj xeeb siab: Tsis muaj kev sib tshuam nrog cov DNA genomic tib neeg qus thiab lwm hom mutant.
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| Tus lej Catalog | Lub Npe Khoom | Cov Lus Qhia Tshwj Xeeb |
| HWTS-TM012A/B | Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Tib Neeg EGFR Gene 29 (Fluorescence PCR) | 16 qhov kev xeem/pawg khoom siv, 32 qhov kev xeem/pawg khoom siv |
| HWTS-TM014A/B | KRAS 8 Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv (Fluorescence PCR) | 24 qhov kev xeem/khoom siv, 48 qhov kev xeem/khoom siv |
| HWTS-TM006A/B | Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Tib Neeg EML4-ALK Fusion Gene (Fluorescence PCR) | 20 qhov kev xeem/pawg khoom siv, 50 qhov kev xeem/pawg khoom siv |
| HWTS-TM009A/B | Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Human ROS1 Fusion Gene (Fluorescence PCR) | 20 qhov kev xeem/pawg khoom siv, 50 qhov kev xeem/pawg khoom siv |
| HWTS-TM007A/B | Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Tib Neeg BRAF Gene V600E (Fluorescence PCR) | 24 qhov kev xeem/khoom siv, 48 qhov kev xeem/khoom siv |
| HWTS-GE010A | Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Cov noob caj noob ces BCR-ABL rau Tib Neeg (Fluorescence PCR) | 24 qhov kev sim/pawg khoom siv |
Lub sijhawm tshaj tawm: Plaub Hlis-17-2023