Txhua txhua xyoo nyob rau lub Plaub Hlis 17th yog hnub tseem ceeb rau kev mob cancer.
01 Ntiaj Teb Cancer Incididence Incence
Nyob rau hauv xyoo tsis ntev los no, nrog kev nce qib tsis tu ncua ntawm tib neeg lub neej thiab kev puas siab puas ntsws, qhov tshwm sim ntawm hlav hlav kuj tseem ua rau xyoo dhau los.
Cov qog ua qog (mob qog nqaij hlav) tau dhau los ua ib qho teeb meem kev noj qab haus huv hauv kev noj qab haus huv hauv Suav teb cov pej xeem. Raws li cov ntaub ntawv txheeb cais tseeb, kev tuag ntawm kev ua phem qog ua raws li 23.91% ntawm cov tub sab thiab kev tuag ntawm kaum xyoo dhau los. Tab sis mob cancer tsis txhais tau tias yog "kab lus tuag." Lub Koom Haum Ntiaj Teb Kev Noj Qab Haus Huv kom pom tseeb tias ntev npaum li nws tau kuaj pom ntxov, 60% -90% ntawm cov qog nqaij hlav tuaj yeem kho tau! Ib feem peb ntawm cov qog nqaij hlav yog tiv thaiv tau, ib feem peb ntawm cov qog nqaij hlav yog los kho tau, thiab ib feem peb ntawm cov qog nqaij hlav tuaj yeem kho tau lub neej ntev.
02 Dab Tsi Yog Lub Hlum
Cov qog yog hais txog cov egernism tshiab tsim los ntawm kev nthuav dav ntawm cov nqaij hauv zos hauv qab kev ua ntawm cov tumorigenic yam. Cov kev tshawb fawb tau pom tias cov qog ntshav dhau cov teeb meem hloov metabolic tau hloov pauv ntawm cov hlwb ib txwm muaj. Nyob rau tib lub sijhawm, cov qog hlwb tuaj yeem hloov kho kom hloov pauv ntawm cov chaw metabolic los ntawm kev hloov ntawm glycolysis thiab oxidative phosphorylation.
03 Kev Kho Mob Cancer Rau Tib Neeg
Kev kho mob cancer rau ib leeg yog ua raws cov ntaub ntawv kev kuaj mob ntawm cov hom phiaj ntawm tus kab mob thiab cov txiaj ntsig ntawm kev tshawb fawb txog kev kho mob. Nws muab lub hauv paus rau cov neeg mob kom tau txais cov phiaj xwm kho kom raug, uas tau dhau los ua tus qauv ntawm kev txhim kho kev kho mob niaj hnub. Cov kev tshawb fawb soj ntsuam tau lees paub tias los ntawm kev hloov pauv cov roj ntsha, gene SNEEN PRODANCE, thiab qhia kev kho mob rau kev ua haujlwm siv tshuaj lom neeg kev tawm tsam, los txhawb kev siv tau kev siv tau kev siv tshuaj kho mob.
Kev sim molecular rau mob cancer tuaj yeem muab faib ua 3 hom tseem ceeb: kuaj mob, keeb kwm kev kho mob, thiab kho. Kho kev tshuaj ntsuam yog nyob ntawm qhov tseem ceeb ntawm thiaj li hu ua "tshuaj kho mob, thiab ntau cov tshuaj txhuam cov khoom tseem ceeb thiab cov phiajcim kev tuaj yeem siv rau kev kho cov qog.
Molecular lub hom phiaj kev kho mob ntawm cov qog ua cov phiaj cim cov qog thiab kev cuam tshuam hauv cov txheej txheem ntawm cov qog nqaij hlav cancous. Nws cov nyhuv feem ntau yog nyob rau cov qog nqaij hlav, tab sis muaj cov nyhuv me me rau cov hlwb ib txwm muaj. Cov qog nqaij cov ntsiab lus tau txais cov lus qhia, teeb liab Transduction, ageraphes cov neeg muaj zog, thiab lwm yam. Txhua yam yuav siv tau ua molecular lub hom phiaj rau qog kev kho. Thaum lub Kaum Ob Hlis 28, 2020, "cov tswj hwm" rau cov neeg kho mob hauv lub tebchaws, cov qauv kev noj qab haus huv kom pom tseeb tias: Cov qauv kev kho mob kom pom tseeb tias: Cov ntsiab cai ntawm kev siv lawv yuav tsum tau ua raws tom qab Lub hom phiaj gene kuaj.
04 cov qog-hom tshuaj ntsuam xyuas caj ces
Muaj ntau hom kev sib hloov caj ces hauv cov qog, thiab sib txawv ntawm cov kev sib txawv ntawm cov tshuaj tiv thaiv genetic siv cov tshuaj sib txawv. Tsuas yog los ntawm qhia meej cov noob hloov pauv thiab xaiv cov tshuaj kho kom raug rau cov neeg mob tau txais txiaj ntsig. Molecular kuaj pom tau raug siv los tshawb xyuas cov kev sib txawv ntawm cov noob muaj feem xyuam rau cov tshuaj uas yog cov tshuaj uas yog cov tshuaj tiv thaiv. Los ntawm kev txheeb xyuas qhov cuam tshuam ntawm cov kev cuam tshuam txog cov caj ces ntawm kev ua tau tshuaj muaj txiaj ntsig, peb tuaj yeem pab cov kws kho mob tsim kev kho mob kom tsim nyog
Kev daws teeb meem 05
Macro & micro-xeem tau tsim cov txheej txheem nrhiav kom mob qog, muab cov kev daws teeb meem tag nrho rau cov qog ua haujlwm.
Tib neeg EGFR Gene 29 Mutle Nrhiav Cov Khoom Siv (Fluorescence pcr)
Cov khoom siv no tau siv rau hauv vitro zoo rau kev sib hloov ntawm cov kev sib hloov pauv 18-21 ntawm EGFR noob hauv tib neeg tsis yog neeg mob cell mob cell.
1. Lub kaw lus qhia txog kev tswj hwm sab hauv kev tswj hwm zoo, uas tuaj yeem nkag siab txog cov txheej txheem sim thiab ua kom qhov zoo ntawm kev sim.
2. Cov siab rhiab: Kev tshawb pom ntawm nucleic acid tshuaj tiv thaiv tov ntawm 1% nyob rau hauv keeb kwm ntawm 3ng / μl tsiaj qus.
3. Qhov tseeb tshwj xeeb: tsis muaj tus ntoo khaub lig-cov tshuaj tiv thaiv nrog rau hom tsiaj qus genomic DNOOM thiab lwm hom Mutant.
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KRAS 8 Mute Nrhiav Khoom Siv (Fluorescence pcr)
Cov khoom siv no yog npaj rau hauv vitro tsim nyog nrhiav tau ntawm 8 hloov nyob rau hauv codons 12 thiab 13 ntawm K-Ras Gene nyob rau hauv tib neeg patholog-emedded patological ntu.
1. Lub kaw lus qhia txog kev tswj hwm sab hauv kev tswj hwm zoo, uas tuaj yeem nkag siab txog cov txheej txheem sim thiab ua kom qhov zoo ntawm kev sim.
2. Cov siab rhiab: Kev tshawb pom ntawm nucleic acid tshuaj tiv thaiv tov ntawm 1% nyob rau hauv keeb kwm ntawm 3ng / μl tsiaj qus.
3. Qhov tseeb tshwj xeeb: tsis muaj tus ntoo khaub lig-cov tshuaj tiv thaiv nrog rau hom tsiaj qus genomic DNOOM thiab lwm hom Mutant.
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Tib neeg eml4-alk fusion gene mution nrhiav khoom siv (fluorescence pcr)
Cov khoom siv no yog siv los tsim nyog soj ntsuam 12 lub zog ntawm eml4-alk fusion gene hauv cov qauv ntawm cov neeg mob c cancer c cancer cancer cancer Cancer Cancer Cov neeg mob cancer hauv Cancer hauv Vitro.
1. Lub kaw lus qhia txog kev tswj hwm sab hauv kev tswj hwm zoo, uas tuaj yeem nkag siab txog cov txheej txheem sim thiab ua kom qhov zoo ntawm kev sim.
2. Kev siab siab: Cov khoom siv no tuaj yeem tshawb xyuas cov fusion sib sau kom tsawg li 20 daim ntawv luam.
3. Qhov tseeb tshwj xeeb: tsis muaj tus ntoo khaub lig-cov tshuaj tiv thaiv nrog rau hom tsiaj qus genomic DNOOM thiab lwm hom Mutant.
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Tib neeg Ros1 Fusion Gene Gene Cov Khoom Siv Mus Nrhiav Kom Tau Khoom Siv (Fluorescence pcr)
Cov khoom siv no yog siv rau hauv venro txaus paub txog ntawm 14 hom ros1 fusion gene hauv tib neeg tsis yog pob tshuaj Cancer me me.
1. Lub kaw lus qhia txog kev tswj hwm sab hauv kev tswj hwm zoo, uas tuaj yeem nkag siab txog cov txheej txheem sim thiab ua kom qhov zoo ntawm kev sim.
2. Kev siab siab: Cov khoom siv no tuaj yeem tshawb xyuas cov fusion sib sau kom tsawg li 20 daim ntawv luam.
3. Qhov tseeb tshwj xeeb: tsis muaj tus ntoo khaub lig-cov tshuaj tiv thaiv nrog rau hom tsiaj qus genomic DNOOM thiab lwm hom Mutant.
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Tib neeg Branf Gene V600E Kev txhaj tshuaj V600E Kev txhaj tshuaj (Fluorescence pcr)
Cov khoom ntsuas no yog siv los ua kom pom cov kab mob siab rau ntawm tib neeg cov qog nqaij hlav cancer, mob cancer thiab ntsws cancer hauv vitro.
1. Lub kaw lus qhia txog kev tswj hwm sab hauv kev tswj hwm zoo, uas tuaj yeem nkag siab txog cov txheej txheem sim thiab ua kom qhov zoo ntawm kev sim.
2. Cov siab rhiab: Kev tshawb pom ntawm nucleic acid tshuaj tiv thaiv tov ntawm 1% nyob rau hauv keeb kwm ntawm 3ng / μl tsiaj qus.
3. Qhov tseeb tshwj xeeb: tsis muaj tus ntoo khaub lig-cov tshuaj tiv thaiv nrog rau hom tsiaj qus genomic DNOOM thiab lwm hom Mutant.
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| Phau Ntawv Teev Npe | Khoom npe | Kev qhia tshwj xeeb |
| HWTS-TM012A / B | Tib neeg EGFR Gene 29 Mutle Nrhiav Cov Khoom Siv (Fluorescence pccr) | 16 Kev Ntsuam Xyuas / Khoom Siv, 32 Testions / Khoom Siv |
| HWTS-TM014A / B | KRAS 8 Mute Nrhiav Khoom Siv (Fluorescence pcr) | 24 Kev Ntsuam Xyuas / Khoom Siv, 48 Xeem / Khoom Siv |
| HWTS-TM006A / B | Tib neeg eml4-alk fusion gene mution nrhiav khoom siv (fluorescence pcr) | 20 Kev Ntsuam Xyuas / Khoom Siv, 50 Kev Tshawb Fawb / Khoom Siv |
| HWTS-TM009A / B | Tib neeg Ros1 Fusion Gene Gene Cov Khoom Siv Mus Nrhiav Kom Tau Khoom Siv (Fluorescence pcr) | 20 Kev Ntsuam Xyuas / Khoom Siv, 50 Kev Tshawb Fawb / Khoom Siv |
| HWTS-TM007A / B | Tib neeg Branf Gene V600E Kev txhaj tshuaj V600E Kev txhaj tshuaj (Fluorescence pcr) | 24 Kev Ntsuam Xyuas / Khoom Siv, 48 Xeem / Khoom Siv |
| HWTS-ge010a | Tib neeg BCR-ABL FUSION GENE GENE GENE MENYUAM nrhiav khoom siv (fluorescence pcr) | 24 Ntsuam Xyuas / Khoom Siv |
Lub Sijhawm Post: Apr-16-202