Riam phom tshiab rau kev kuaj mob ntsws thiab tshuaj yeeb tshuaj
Daim Ntawv Qhia Ntaub Ntawv: CCA: Tus qauv kuaj mob raws li TNGs thiab tshuab kev kawm, uas haum rau cov neeg muaj cov kab mob tsawg dua thiab tuberculle.
Thesis npe: Tuberculous-haub-hom kev sib tw tom ntej-tiam tom ntej-tiam kev kawm ua ntu zus: ib qho ultra-rhiab kuaj mob rau PAUCIcary tubular thiab tubular meningitis.
Piam Sij Hawm: "Clinica Acta"
Yog tias: 6.5
Hnub tshaj tawm: Lub Ib Hlis 2024
Ua ke nrog University of Suav Academy of Sciency thiab Beijing hauv siab cov qauv ntawm cov qauv kev kho mob tshiab (tNRS) thev naus laus zis thiab tshuab kev kawm, uas tau muab ultra-siab Kev Tshawb Nrhiav Kev Mob Siab rau Tuberculosis nrog cov kab mob ntsws thiab tuberculous ceningitis, muab kev ntsuas siab tshiab rau kev kuaj mob rau kev kuaj mob ntawm ob hom Tuberculosis, thiab pab tau qhov tseeb kuaj mob, tshuaj yeeb tshuaj thiab kho mob ntsws. Nyob rau tib lub sijhawm, nws pom tias tus neeg mob ntshav siab mob CFDNA tuaj yeem siv ua cov qauv tsim nyog rau kev kuaj mob ntawm TBM.
Hauv txoj kev tshawb fawb no, 227 ntshav kuaj thiab cerebrospinal kua tshuaj tau siv los tsim ob lub chaw kuaj mob corryculists tau siv los kuaj cov qauv ntawm tubrogrles tau siv los xyuas cov txheej txheem Kev kuaj qauv. Tag nrho cov qauv tau ua thawj zaug tau tsim los ntawm kev tsim tshwj xeeb tsim kev tshawb fawb ua pas dej ua si rau mycobacterium tuberculosis. Tom qab ntawd, raws li TB-tng Cov tau pib pib tau coj mus rau ob xeem kev kuaj mob rau kev kuaj pom, thiab kev kuaj mob ntawm tus neeg kawm tau ntsuas los ntawm Roc Nkhaus. Thaum kawg, kuaj qauv ntawm tuberculosis tau txais.
Daim duab 1 schematic daim duab ntawm kev tshawb fawb tsim
Cov txiaj ntsig: raws li qhov kev ntsuas ntawm CSF DNA (AUC = 0.974) thiab cov qauv ntawm CSF yog 97.01%, qhov tshwj xeeb yog 95.65%, thiab Cov kev nkag siab thiab qhov tshwj xeeb ntawm cov qauv ntshav yog 82.61% thiab 86.36%. Hauv kev tsom xam ntawm 44 ua piv txwv ntawm ntshav cfdna thiab cerebrospospinal kua dej DNA muaj kev sib cav sib ceg (42/44). Nyob rau hauv cov menyuam yaus nrog carmonary tuberculosis, cov kev kuaj mob ntawm cov kev tshawb fawb mob plab zom mov ntawm tib tus neeg mob (28.57% vs 15.38%).
Daim duab 2 Kev Tshawb Fawb Kev Tshawb Fawb Txog Kev Mob Tub Rog Tub Rog
Daim duab 3 Cov txiaj ntsig kuaj mob ntawm kev sib tw
Xaus: Kev kuaj mob rau kev kuaj mob rau tuberculosis tau tsim nrog cov neeg mob kho mob rau cov neeg mob kho mob nrog oligobacillary tuberculosis (kab lis kev cai tsis zoo). Nrhiav tau ntawm hypersensitive tuberculosis raws li ntshav cfdna tej zaum yuav yooj yim qauv yog yooj yim dua cerebrospinal (ntshavcencench cov kua dej rau cov neeg mob lub hlwb ntawm tuberculosis).
Thawj qhov txuas: httw.sciencedirectr.com/scence/article/pii/s0009898123004990? ntawm% 3dihub
Luv luv Cov Lus Qhia Ntawm Macro & micro-xeem tuberculosis series nrhiav khoom
Hauv kev pom ntawm cov qauv kev nyuaj ntawm cov tuberculosis thiab ntau yam kev xav tau muab cov qauv kev sib tw ua tiav kev sib tw, cov tsev qiv ntawv microScomic los ntawm cov qauv kev sib tw, cov tsev qiv ntawv muaj zog tsim thiab ua ntu zus, thiab cov ntaub ntawv tsom xam. Cov khoom lag luam npog sai kuaj mob ntawm cov tuberculosis thiab NTM, kev mob ntsws thiab cov neeg npau taws thiab tuberculous neeg, thiab lwm yam.
Cov khoom siv kom paub txog kev ua tuberculosis thiab myCobacteria:
| Yam khoom tsis tau | Khoom npe | Cov Khoom Kuaj Khoom | Qauv Hom | Muaj Qauv Qauv |
| HWTS-3012 | Qauv Tso Tawm Tso Cai | Siv nyob rau hauv kev kho liquefaction ntawm SPUTUM cov qauv, tau tau txais thawj-chav sau cov naj npawb, sutong tshuab khoom siv 20230047. | nto | |
| Hwts-ngs-p00021 | Cov Khoom Siv Ntau Kom Tau Txiaj Ntsig Rau Kev Mob Siab Rau Kev Mob Tub Rog (Kev Soj Ntsuam) | Tsis yog-intinas (kua biopsy) kev siv rau cov kab mob-tsis zoo ntsws ntsws tuberculosis thiab nodules; Cov qauv ntawm cov neeg xav tias yuav kis tus mob ntsws qhuav lossis tsis muaj tuberculosis lossis cov ntaub ntawv tsis muaj mob ntsws uas tsis yog tus kab mob ua ntej tau muab. | Peripheral ntshav, alveolle fluws, hydrothorax thiab ascites, tsom cov qauv, cerebrospinal kua. | Thib ob tiam |
| HWTS-NGS-T001 | MyCobacterium typing thiab Yeeb Tshuaj Tiv Thaiv thiab Tshuaj Tsuag Yeeb Yam Kev Ua Yeeb Yam) | Mycobacterium ntaus ntawv kuaj, suav nrog MTBC thiab 187 NTM;Tshuaj tsis kam lees paub txog mycobacterium tuberculised thiab 16 qhov kev sib hloov pauv ntawm cov tshuaj tiv thaiv noob. | Cov hnoos qeev, cov tshuaj pleev li alveolle ua kua, hydrothorax thiab ascites, tsom cov qauv, cerebrospinal kua. | Thib ob / lub zog siab dua sual platform |
Cov ntsiab lus tseem ceeb: HWTS-NGS-T001 myCobacterium typing thiab Yeeb Tshuaj Tsis Zoo Rau Cov Qauv (CONDX amplifications)
Khoom Taw Qhia
Cov khoom lag luam yog raws li cov tshuaj tseem ceeb-thiab cov tshuaj thib ob tau piav qhia nyob rau hauv cov lus qhia kev kho mob TB, cov tshuaj aminoglycosides feem ntau yog cov chaw tshuaj tiv thaiv kab mob, thiab cov chaw tshuaj tiv thaiv-muaj feem ntsig txog qhov chaw Leej myCobacterium tuberculosis nyuaj clealog, ntxiv rau lwm cov yeeb tshuaj uas tau tshaj tawm cov tshuaj thiab cov kev sib hloov pauv raws li kev tshawb nrhiav thiab txheeb cais ntawm Cov ntawv nyeem siab tshaj plaws nyob hauv tsev thiab txawv tebchaws.
Kev cim rau kev txheeb xyuas yog ua raws NPM hom kab ke hauv NTM cov lus qhia luam tawm los ntawm Suav teb cov xov xwm ntawm cov kws paub. Cov ntawv tsim cov ntawv sau cia tsim muaj peev xwm ua kom nrov dua, sib lawv liag thiab annotate ntau tshaj 190 NTM hom.
Los ntawm kev tsom xam cov noob groucation thiab cov yeeb tshuaj tiv thaiv yeeb tshuaj thiab cov tshuaj tiv thaiv yeeb yaj kiab ntawm cov hom phiaj ntawm cov hom phiaj tau ua kom tau txais. Cov khoom lag luam amplified tuaj yeem tsim mus rau hauv cov tsev qiv ntawv thib ob, thiab tag nrho cov kev ua ntu zus thib peb tuaj yeem raug cov ntaub ntawv ntawm cov ntaub ntawv sib txawv. Los ntawm kev sib piv nrog cov kev paub sib hloov muaj nyob hauv cov ntaub ntawv ua haujlwm (suav nrog cov neeg mycobacterium tuberculisations lossis kev sib raug zoo ntawm cov tshuaj tiv thaiv kab mob ntawm cov tuberculosis tau txiav txim siab. Ua ke nrog tus kheej qhib hnoos qeev ntawm macro & micro-xeem, qhov teeb meem ntawm cov qauv me me uas tau daws teeb meem) yog daws cov tshuaj ib txwm muaj tuaj yeem yog ncaj qha rau kev kuaj mob hnoos qeev.
Nrhiav kom tau txais cov khoom lag luam
34Cov tshuaj tiv thaiv-cuam tshuam txog noob18anti-tuberculosis tshuaj thiab6NTM cov tshuaj raug kuaj pom, npog297Tshuaj tiv thaiv cov chaw; Kaum hom myCobacterium tuberculosis thiab ntau dua190hom NTM raug kuaj pom.
Cov lus 1: Cov ntaub ntawv ntawm 18 + 6 cov yeeb tshuaj +0 + NTM
Cov khoom kom zoo dua
Cov chaw kuaj mob muaj peev xwm hloov tau: Cov hnoos qeev tuaj yeem raug kuaj pom ncaj qha nrog tus kheej liquefaction tus neeg sawv cev tsis muaj kab lis kev cai.
Kev ua haujlwm sim yog yooj yim: thawj zaug ua haujlwm ua haujlwm yooj yim, thiab lub tsev qiv ntawv kev siv tau ua tiav hauv 3 teev, uas txhim kho kev ua haujlwm ua haujlwm.
Kev ntaus nqi ntaus thiab tshuaj tsis kam: Npog cov ntaus ntawv kev txhawj xeeb thiab cov tshuaj tiv thaiv kev ywj pheej, thiab cov kev soj ntsuam tsom xam nrog tus lej.
Kev sib raug zoo: Cov khoom lag luam sib xyaw, hloov mus rau Mainstream Ilm thiab Mgi / ont platform.
Khoom Qhia Txog Khoom
| Khoom Code | Khoom npe | Nrhiav tau lub platform | Cov lus qhia |
| HWTS-NGS-T001 | MyCobacterium typing thiab Yeeb Tshuaj Yuav Tsum Siv thiab Tshuaj Yeeb Tshuaj) | Ont, itchina, mgi, salus pro | 16 / 96RXN |
Lub Sijhawm Post: Jan-23-2024