Kev tshuaj xyuas ntawmDaim ntawv tshawb fawb Classic
Respiratory Syncytial Virus (RSV) thiab Human Metapneumovirus (HMPV) yog two cov kab mob zoo sib xws hauv covPneumoviridaetsev neeguas feem ntau tsis meej pem nyob rau hauv cov neeg mob ntawm tus me nyuam mob ua pa kab mob. Thaum lawv cov kev nthuav qhia kho mob sib tshooj, cov ntaub ntawv soj ntsuam yav tom ntej (2016-2020) los ntawm 7 US cov tsev kho mob menyuam yaus - suav nrog 8,605 tus neeg mob - nthuav tawm qhov sib txawv tseem ceeb hauv lawv cov neeg muaj kev pheej hmoo siab, kab mob hnyav, thiab kev tswj xyuas kev kho mob. Txoj kev tshawb no tau ua haujlwm ib qho kev ua haujlwm zoo, kev tsim yav tom ntej nrog kev sau cov kab mob nasopharyngeal swab thiab kuaj rau 8 tus kab mob ua pa, muab thawj qhov loj, qhov sib piv tiag tiag rau cov kws kho mob. Los ntawm kev txheeb xyuas tus nqi pw hauv tsev kho mob, kev nkag mus rau ICU, kev siv tshuab ua pa, thiab kev nyob hauv tsev kho mob ntev (≥3 hnub), nws tsim ib qho tseem ceeb ua ntej kev cuam tshuam kev sib kis kab mob hauv paus rau lub sijhawm ntawm kev txhaj tshuaj RSV tshiab (xws li, tshuaj tiv thaiv niam txiv, cov tshuaj tiv thaiv kab mob monoclonal ntev ntev) thiab tsim HM PV vaccine txoj kev loj hlob yav tom ntej.
Qhov Tseem Ceeb Nrhiav 1: Cov Profiles uas pheej hmoo siab sib txawv
-RSV feem ntau cuam tshuam rau cov me nyuam mos:Lub hnub nyoog nruab nrab ntawm kev mus pw hauv tsev kho mob tsuas yog 7 lub hlis, nrog 29.2% ntawm cov neeg mob tau txais kev kho mob yog cov menyuam mos (0-2 lub hlis). RSV yog ib qho tseem ceeb ntawm kev mus pw hauv tsev kho mob hauv cov menyuam mos hnub nyoog qis dua 6 lub hlis, nrog qhov hnyav sib cuam tshuam nrog lub hnub nyoog.
-HMPV tsom rau cov menyuam yaus thiab cov uas muaj kab mob sib kis:Lub hnub nyoog nruab nrab ntawm kev mus pw hauv tsev kho mob yog 16 lub hlis, muaj kev cuam tshuam ntau dua rau cov menyuam yaus tshaj 1 xyoos. Qhov tseem ceeb, feem ntau ntawm cov mob hauv qab no (xws li, hlab plawv, paj hlwb, ua pa) yog ntau tshaj ob npaug ntawm cov neeg mob HMPV (26%) piv rau cov neeg mob RSV (11%), qhia txog lawv qhov kev pheej hmoo siab.
Daim duab 1. Kev faib tawm hnub nyoog ntawm ED mus ntsib thiab mus pw hauv tsev kho mobtxuam nrog RSV lossis HMPV
hauv cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Qhov Tseem Ceeb Nrhiav 2: Sib txawv ntawm kev nthuav qhia kho mob
-RSV manifests nrog cov cim tseem ceeb ntawm kev ua pa qis:Nws muaj feem cuam tshuam nrog bronchiolitis (76.7% ntawm cov mob hauv tsev kho mob). Cov cim tseem ceeb suav nrogLub hauv siab phab ntsa retractions (76.9% cov neeg mob; 27.5% ED)thiabtachypnea (91.8% cov neeg mob; 69.8% ED), ob qho tib si tseem ceeb dua li hauv HMPV.
-HMPV muaj qhov ua npaws thiab mob ntsws ntau dua:Pneumonia tau kuaj pom hauv 35.6% ntawm cov neeg mob HMPV hauv tsev kho mob - ob npaug ntawm tus nqi RSV.Ua npaws yog qhov tseem ceeb tshaj plaws (83.6% cov neeg mob; 81% ED). Thaum cov tsos mob ua pa xws li hawb pob thiab tachypnea tshwm sim, lawv feem ntau tsis tshua hnyav dua li ntawm RSV.
Daim duab 2.Cov yam ntxwv sib piv thiab kev kho mobchav kawmntawm RSV vs. HMPV hauv cov menyuam yaus hnub nyoog qis dua 18 xyoo.
Cov ntsiab lus: RSVFeem ntau ua rau mob hnyav rau cov menyuam mos, uas yog qhov ua rau muaj kev nyuaj siab ua pa (hheezing, retractions) thiab bronchiolitis.HMPVFeem ntau cuam tshuam rau cov menyuam yaus uas muaj kev sib txawv, tshwm sim nrog ua npaws, ua rau muaj kev pheej hmoo ntau dua ntawm kev mob ntsws, thiab feem ntau ua rau muaj kev cuam tshuam ntau dua.
Qhov Tseem Ceeb Nrhiav 3: Lub Caij Nplooj Ntoos Zeeg Teeb Meem
-RSV muaj qhov ntxov, kwv yees qhov siab tshaj plaws:Nws cov dej num yog siab concentrated, feem ntau peaking ntawmKaum Ib Hlis thiab Lub Ib Hlis, ua rau nws yog thawj kab mob hem thawj rau cov menyuam mos nyob rau lub caij nplooj zeeg thiab lub caij ntuj no.
-HMPV peaks tom qab nrog ntau qhov sib txawv:Nws lub caij tuaj txog tom qab, feem ntau peakingLub Peb Hlis thiab Plaub Hlis, thiab ua qauv qhia tseem ceeb xyoo-rau-xyoo thiab kev hloov pauv hauv cheeb tsam, feem ntau tshwm sim raws li "nthwv dej thib ob" tom qab RSV poob qis.
Daim duab 3.Zuag qhia tag nrho thiab qhov chaw tshwj xeeb PCR positiveetus nqi rau RSV thiab HMPV ntawm cov menyuam yaus hnub nyoog qis dua 18 xyoo uas muaj tus kab mob ua pa nyuaj (ARI) - koom nrog ED mus ntsib thiab mus pw hauv tsev kho mob.
Kev Tiv Thaiv thiab Kev Saib Xyuas: Daim phiaj xwm ua pov thawj-raws li
-RSV Prophylaxis:Cov tswv yim tiv thaiv tam sim no muaj. Xyoo 2023, US FDA tau pom zoo rau cov tshuaj tiv thaiv kab mob monoclonal ntev (Nirsevimab), uas tuaj yeem tiv thaiv cov menyuam mos rau lawv thawj 5 lub hlis. Tsis tas li ntawd, kev txhaj tshuaj tiv thaiv niam txiv RSV muaj txiaj ntsig zoo hloov cov tshuaj tiv thaiv kab mob rau cov menyuam mos.
-HMPV Prophylaxis:Tam sim no tsis muaj cov tshuaj tiv thaiv pom zoo. Txawm li cas los xij, ntau tus neeg sib tw tshuaj tiv thaiv (xws li, AstraZeneca's RSV / HMPV ua ke tshuaj tiv thaiv) yog nyob rau hauv kev sim tshuaj. Cov niam txiv raug qhia kom nyob twj ywm paub txog cov xov xwm tshiab los ntawm tsoomfwv saib xyuas kev noj qab haus huv.
Nrhiav Kev Saib Xyuas Kev Kho Mob tam sim rau txhua yam ntawm "Red Flags":
-Ua npaws hauv menyuam mos:Kub ≥38 ° C (100.4 ° F) rau txhua tus menyuam mos hnub nyoog qis dua 3 lub hlis.
-Ua pa nce siab:Ua pa tshaj 60 pa ib feeb rau cov me nyuam mos 1-5 lub hlis, los yog 40 ua pa ib feeb rau cov me nyuam 1-5 xyoos, qhia tau hais tias muaj peev xwm ua pa nyuaj.
-Tsawg Oxygen Saturation:Oxygen saturation (SpO₂) poob qis dua 90%, ib qho cim tseem ceeb ntawm kev mob hnyav pom nyob rau hauv 30% ntawm RSV thiab 32.1% ntawm HMPV tsev kho mob hauv txoj kev tshawb no.
-Lethargy lossis Feeding Difficulties:Qhov tseem ceeb lethargy los yog txo cov mis noj ntau tshaj li ib feem peb hauv 24 teev, uas tuaj yeem ua rau lub cev qhuav dej.
Txawm hais tias qhov sib txawv ntawm kev kis mob thiab kev nthuav qhia kho mob, qhov sib txawv ntawm RSV thiab HMPV ntawm qhov kev saib xyuas tseem nyuaj. Tsis tas li ntawd, kev hem thawj ntawm kev kho mob txuas ntxiv mus dhau ob tus kab mob no, nrog rau cov kab mob xws li mob npaws A thiab cov kab mob ntawm lwm cov kab mob thiab kab mob ua rau muaj kev hem thawj rau pej xeem kev noj qab haus huv. Kev kuaj mob raws sij hawm thiab meej etiological yog li tseem ceeb heev rau kev tswj hwm kev txhawb nqa, kev sib cais zoo, thiab kev faib cov peev txheej muaj txiaj ntsig.
Qhia txog AIO800 + 14-Pathogen Combined Detection Kit (Fluorescence PCR)(NMPA, CE, FDA, SFDA pom zoo)
Yuav kom ua tau raws li qhov kev thov no, lubEudemon ™ AIO800 Tag Nrho Tsis Siv Neeg Nucleic Acid Detection System, ua ke nrog a14-pathogen pa vaj huam sib luag, muab kev daws teeb meem - xa qhov tseeb"Sample in, teb tawm"kuaj mob hauv 30 feeb xwb.
Qhov kev kuaj ua pa dav dav no kuaj poms ob yam kab mob thiab kab moblos ntawm ib qho piv txwv, ua rau cov kws kho mob pem hauv ntej kom ntseeg siab, raws sijhawm, thiab kev txiav txim siab kho mob.
Cov Txheej Txheem Tseem Ceeb uas tseem ceeb rau koj cov neeg siv khoom
Fully Automated Workflow
Siv sijhawm tsawg dua 5 feeb. Tsis xav tau cov neeg ua haujlwm molecular txawj.
- Cov txiaj ntsig ceev
Lub sijhawm hloov pauv ntawm 30 feeb txhawb kev kho mob sai.
- 14Pathogen Multiplex Detection
Simultaneous identification ntawm:
Kab mob:COVID-19, Influenza A & B, RSV, Adv, hMPV, Rhv, Parainfluenza types I-IV, HBoV, EV, CoV
Cov kab mob:MP,Cpn, SP
-Lyophilized Reagents ruaj khov ntawm chav kub (2-30 ° C)
Simplifies cia thiab kev thauj mus los, tshem tawm cov kab mob khaub thuas-chain dependency.
Robust Contamination Prevention System
11-txheej txheej tiv thaiv kab mob xws li UV sterilization, HEPA pom, thiab kaw-cartridge workflow, thiab lwm yam.
Kev txheeb xyuas cov kab mob nrawm nrawm yog lub hauv paus rau kev tswj hwm niaj hnub ntawm cov kab mob ua pa rau menyuam yaus. Lub AIO800 system, nrog nws cov automated tag nrho, 30-feeb, multiplex PCR vaj huam sib luag, muab cov tswv yim daws teeb meem rau pem hauv ntej chaw. Los ntawm kev ua kom muaj kev tshawb pom ntxov thiab raug ntawm RSV, HMPV, thiab lwm yam kab mob tseem ceeb, nws ua rau cov kws kho mob txiav txim siab txog kev kho mob, txhim kho kev siv tshuaj tua kab mob, thiab siv kev tswj kev kis kab mob zoo-thaum kawg txhim kho kev saib xyuas neeg mob thiab kev noj qab haus huv.
#RSV #HMPV # Ceev ceev #Kev qhia # Ua pa # Kab mob # Qauv-rau- teb#MacroMicroTest
Post lub sij hawm: Dec-02-2025