Raws li daim ntawv tshaj tawm txog mob qog noj ntshav thoob ntiaj teb tshiab kawg, mob qog noj ntshav ntsws tseem yog qhov ua rau neeg tuag ntau tshaj plaws los ntawm mob qog noj ntshav thoob ntiaj teb, suav txog 18.7% ntawm tag nrho cov neeg tuag hauv xyoo 2022. Feem ntau ntawm cov neeg mob no yog mob qog noj ntshav ntsws tsis me (NSCLC). Txawm hais tias kev siv tshuaj kho mob rau cov kab mob hnyav tau muab txiaj ntsig tsawg, tus qauv tau hloov pauv loj heev.
Qhov kev tshawb pom cov cim qhia tseem ceeb, xws li EGFR, ALK, thiab ROS1, tau hloov pauv kev kho mob, hloov nws los ntawm ib txoj hauv kev uas haum rau txhua tus mus rau txoj hauv kev meej uas tsom mus rau cov yam ntxwv tshwj xeeb ntawm txhua tus neeg mob qog noj ntshav.
Txawm li cas los xij, kev vam meej ntawm cov kev kho mob hloov pauv no yog nyob ntawm kev kuaj noob caj noob ces kom raug thiab txhim khu kev qha kom paub lub hom phiaj zoo rau tus neeg mob zoo.
Cov Cim Tseem Ceeb: EGFR, ALK, ROS1, thiab KRAS
Plaub lub cim qhia txog kab mob (biomarkers) sawv cev ua lub hauv paus tseem ceeb hauv kev kuaj mob molecular ntawm NSCLC, coj kev txiav txim siab kho mob thawj kab:
-EGFR:Qhov kev hloov pauv uas muaj ntau tshaj plaws, tshwj xeeb tshaj yog rau cov neeg Esxias, poj niam, thiab cov neeg tsis haus luam yeeb. Cov tshuaj EGFR tyrosine kinase inhibitors (TKIs) zoo li Osimertinib tau ua rau cov neeg mob tau txais txiaj ntsig zoo dua.
-ALK:Qhov "kev hloov pauv pob zeb diamond," uas muaj nyob rau hauv 5-8% ntawm cov neeg mob NSCLC. Cov neeg mob uas muaj ALK fusion-positive feem ntau teb tau zoo rau ALK inhibitors, ua rau lawv muaj sia nyob ntev.
-ROS1:Muaj cov qauv zoo sib xws li ALK, qhov "pov thawj tsis tshua muaj" no tshwm sim hauv 1-2% ntawm cov neeg mob NSCLC. Muaj cov kev kho mob zoo rau lub hom phiaj, ua rau nws tseem ceeb heev.
-KRAS:Keeb kwm suav tias yog "tsis muaj tshuaj kho tau," KRAS mutations yog ib qho uas pom ntau. Kev pom zoo tsis ntev los no ntawm KRAS G12C inhibitors tau hloov cov biomarker no los ntawm ib qho cim qhia txog kev kwv yees mus rau hauv ib qho lub hom phiaj ua tau, hloov pauv kev kho mob rau cov neeg mob no.
Cov Ntaub Ntawv MMT: Tsim los rau Kev Ntseeg Siab rau Kev Kuaj Mob
Txhawm rau kom tau raws li qhov xav tau ceev ceev rau kev txheeb xyuas cov cim biomarker kom meej, MMT muaj cov khoom lag luam ntawm CE-IVD cim lub sijhawm tiag tiagCov khoom siv kuaj mob PCR, txhua tus tau tsim los nrog cov thev naus laus zis tshiab kom ntseeg tau tias muaj kev ntseeg siab rau kev kuaj mob.
1. Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm EGFR
-Kev Siv Tshuab ARMS Zoo Dua:Cov tshuaj txhim kho tshwj xeeb ua rau muaj kev hloov pauv loj dua.
-Kev ua kom muaj zog ntawm cov enzymes:Cov tshuaj restriction endonucleases zom cov keeb kwm yav dhau los ntawm cov noob caj noob ces qus, ua kom cov kab ke mutant nplua nuj thiab txhim kho kev daws teeb meem.
-Kev Thaiv Kub:Ib kauj ruam thermal tshwj xeeb txo cov priming uas tsis tshwj xeeb, thiab txo qis cov keeb kwm yav dhau los qus.
-Cov txiaj ntsig tseem ceeb:Kev rhiab heev tsis sib xws mus txog1%zaus allele hloov pauv, qhov tseeb zoo heev nrog kev tswj sab hauv thiab UNG enzyme, thiab lub sijhawm tig rov qab sai ntawm kwv yees li120 feeb.
- Sib xws nrogob qho tib si cov qauv biopsy nqaij thiab kua.
- MMT EML4-ALK Fusion Detection Kit
- Kev rhiab heev:Nrhiav tau qhov kev hloov pauv fusion nrog qhov txwv qis ntawm kev nrhiav tau 20 daim ntawv theej/kev cuam tshuam.
-Kev Tseeb Zoo Kawg Nkaus:Suav nrog cov qauv sab hauv rau kev tswj cov txheej txheem thiab UNG enzyme los tiv thaiv kev kis kab mob, zam kev cuav cuav thiab tsis zoo.
-Yooj Yim & Ceev:Muaj kev ua haujlwm yooj yim, kaw-lub raj ua tiav hauv kwv yees li 120 feeb.
-Kev Sib Txuas Lus ntawm Cov Cuab Yeej:Adaptable rau ntau yam kev sivcov cuab yeej PCR tiag tiag, muab kev ywj pheej rau txhua qhov chaw kuaj mob.
- MMT ROS1 Fusion Detection Kit
Kev rhiab heev:Qhia tau tias muaj kev ua tau zoo heev los ntawm kev ntes tau tsawg li 20 daim ntawv theej/kev cuam tshuam ntawm cov hom phiaj sib xyaw.
Kev Tseeb Zoo Kawg Nkaus:Kev siv cov kev tswj xyuas zoo sab hauv thiab UNG enzyme ua kom ntseeg tau tias txhua qhov txiaj ntsig ntseeg tau, txo qhov kev pheej hmoo ntawm kev tshaj tawm qhov yuam kev.
Yooj Yim & Ceev:Ua ib lub kaw-tube system, nws tsis tas yuav muaj cov kauj ruam tom qab amplification nyuaj. Cov txiaj ntsig zoo thiab txhim khu kev qha tau txais hauv li 120 feeb.
Kev Sib Txuas Lus ntawm Cov Cuab Yeej:Tsim los rau kev sib raug zoo dav dav nrog ntau yam tshuab PCR tseem ceeb, ua kom yooj yim rau kev koom ua ke rau hauv cov haujlwm ua haujlwm hauv chaw kuaj mob uas twb muaj lawm.
- Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm MMT KRAS
- Kev siv tshuab ARMS zoo dua, txhawb nqa los ntawm Enzymatic Enrichment thiab Temperature Blocking.
- Kev ua kom muaj zog ntawm cov enzymes:Siv cov restriction endonucleases los xaiv cov keeb kwm yav dhau los genomic qus, yog li ua kom cov kab ke mutant nplua nuj thiab txhim kho qhov kev daws teeb meem ntawm kev kuaj pom.
-Kev Thaiv Kub:Qhia txog ib kauj ruam kub tshwj xeeb los ua kom muaj kev tsis sib xws ntawm cov primers tshwj xeeb mutant thiab cov qauv qus, txo qhov keeb kwm yav dhau los thiab txhim kho qhov tshwj xeeb.
- Kev rhiab heev:Ua tiav qhov kev rhiab heev ntawm 1% rau cov alleles mutant, xyuas kom meej tias muaj kev hloov pauv tsawg.
-Kev Tseeb Zoo Kawg Nkaus:Cov qauv sab hauv thiab UNG enzyme tiv thaiv cov txiaj ntsig tsis zoo thiab tsis zoo.
-Vaj Huam Sib Luag:Tau teeb tsa zoo kom yooj yim nrhiav tau yim qhov kev hloov pauv KRAS sib txawv thoob plaws ob lub raj tshuaj tiv thaiv.
- Yooj Yim & Ceev:Muab cov txiaj ntsig zoo thiab txhim khu kev qha hauv kwv yees li 120 feeb.
- Kev Sib Txuas Lus ntawm Cov Cuab Yeej:Haum rau ntau yam PCR cov cuab yeej, muab kev ywj pheej rau cov chaw kuaj mob.
Vim li cas ho xaiv MMT NSCLC Solution?
Kev Nkag Siab: Ib qho chaw tiav rau plaub qhov tseem ceeb tshaj plaws ntawm NSCLC biomarkers.
Kev Siv Tshuab Zoo Tshaj Plaws: Kev txhim kho tshwj xeeb (Enzymatic Enrichment, Temperature Blocking) ua kom muaj kev tshwj xeeb thiab kev rhiab heev qhov twg nws tseem ceeb tshaj plaws.
Ceev & Zoo: Cov txheej txheem sib xws ~ 120-feeb thoob plaws cov ntaub ntawv ua kom lub sijhawm kho mob sai dua.
Yooj Yim Siv Tau & Nkag Tau: Sib xws nrog ntau hom qauv thiab cov cuab yeej PCR tseem ceeb, txo cov teeb meem kev siv.
Xaus lus
Nyob rau lub caij nyoog ntawm kev kho mob qog nqaij hlav uas raug tseeb, kev kuaj mob molecular yog lub koob qhia kev uas coj kev kho mob. MMT cov khoom siv kuaj mob siab heev ua rau cov kws kho mob muaj peev xwm kos duab cov noob caj noob ces ntawm tus neeg mob NSCLC, qhib lub peev xwm cawm txoj sia ntawm kev kho mob tsom mus rau.
Contact to learn more: marketing@mmtest.com
Lub sijhawm tshaj tawm: Kaum Ib Hlis-05-2025