Kev hloov pauv hauv KRAS cov noob muaj feem cuam tshuam rau ntau hom qog nqaij hlav hauv tib neeg, nrog kev hloov pauv ntawm kwv yees li 17% -25% ntawm cov qog nqaij hlav, 15% -30% mob qog noj ntshav, thiab 20% -50% mob qog noj ntshav. Cov kev hloov pauv no ua rau muaj kev kho mob tsis zoo thiab qog nqaij hlav los ntawm lub hauv paus tseem ceeb: P21 protein encoded los ntawm KRAS ua haujlwm hauv qab ntawm EGFR teeb liab txoj hauv kev. Thaum KRAS tau hloov pauv, nws ib txwm ua rau cov kev taw qhia qis qis, ua rau EGFR-targeted kev kho mob tsis zoo thiab ua rau muaj kev cuam tshuam ntawm cov cell proliferation. Raws li qhov tshwm sim, KRAS kev hloov pauv tau cuam tshuam nrog kev ua haujlwm ntawm EGFR tyrosine kinase inhibitors hauv kev mob ntsws cancer thiab tshuaj tiv thaiv EGFR tshuaj tiv thaiv kab mob hauv plab hnyuv.

Xyoo 2008, National Comprehensive Cancer Network (NCCN) tau tsim cov txheej txheem kho mob pom zoo rau KRAS kev hloov pauv rau txhua tus neeg mob uas mob qog nqaij hlav hauv plab (mCRC) ua ntej kho. Cov txheej txheem qhia tau hais tias feem ntau ntawm kev ua kom KRAS kev hloov pauv tshwm sim hauv codons 12 thiab 13 ntawm exon 2. Yog li, kev kuaj pom KRAS kev hloov pauv sai thiab raug yog qhov tseem ceeb rau kev coj ua kev kho mob tsim nyog.

Vim li cas KRAS Kev Xeem yog qhov tseem ceeb hauvMetastaticColorectalCancer(mCRC)

Kev mob qog nqaij hlav hauv plab (CRC) tsis yog ib qho kab mob nkaus xwb tab sis yog ib qho kev sib sau ntawm cov kab mob sib txawv ntawm cov kab mob. KRAS kev hloov pauv-tam sim no nyob rau hauv kwv yees li 40-45% ntawm CRC cov neeg mob-ua raws li kev hloov pauv tas li, txhawb kev mob qog noj ntshav tsis muaj kev cuam tshuam sab nraud. Rau cov neeg mob mCRC, KRAS raws li txoj cai txiav txim siab qhov ua tau zoo ntawm cov tshuaj tiv thaiv EGFR monoclonal antibodies xws li Cetuximab thiab Panitumumab:

Wild-Type KRAS:Cov neeg mob yuav tau txais txiaj ntsig los ntawm kev kho EGFR.

Mutant KRAS:Cov neeg mob tsis tau txais txiaj ntsig los ntawm cov neeg ua haujlwm no, muaj kev pheej hmoo rau cov kev mob tshwm sim tsis tsim nyog, nce nqi, thiab qeeb hauv kev kho kom zoo.

Qhov tseeb thiab rhiab KRAS kuaj yog li ntawd lub hauv paus ntawm kev npaj kho tus kheej.

Kev Tshawb Nrhiav Kev Sib Tw: Kev cais tawm qhov hloov pauv

Cov txheej txheem ib txwm muaj feem ntau tsis muaj kev nkag siab zoo rau cov kev hloov pauv uas tsis tshua muaj, tshwj xeeb tshaj yog nyob rau hauv cov qauv nrog cov qog nqaij hlav qis lossis tom qab decalcification. Qhov nyuaj yog qhov txawv ntawm qhov tsis zoo ntawm DNA mutant teeb liab tawm tsam cov keeb kwm yav dhau los-zoo li nrhiav ib rab koob hauv haystack. Cov txiaj ntsig tsis raug tuaj yeem ua rau muaj kev kho mob tsis raug thiab qhov tshwm sim tsis zoo.

Peb qhov kev daws teeb meem: Precision-Engineered rau kev ntseeg siab hloov mus kuaj

Peb KRAS Mutation Detection Kit koom ua ke cov thev naus laus zis siab dhau los kov yeej cov kev txwv no, muab qhov tseeb tshwj xeeb thiab kev ntseeg siab rau mCRC cov lus qhia kho mob.

Yuav Ua Li Cas Peb Lub Tshuab Ua kom muaj kev ua tau zoo tshaj plaws

• Txhim kho ARMS thev naus laus zis (Amplification Refractory Mutation System): Tsim los ntawm ARMS thev naus laus zis, suav nrog cov cuab yeej ua kom zoo tshaj plaws los ua kom pom qhov tseeb.
• Enzymatic Enrichment: Siv cov kev txwv endonucleases los zom cov feem ntau ntawm tib neeg genome cov tsiaj qus keeb kwm yav dhau, sparing mutant hom, yog li txhim kho kev daws teeb meem thiab txo qhov tsis muaj kev nthuav dav vim muaj keeb kwm genomic siab.
• Kev Tiv Thaiv Kev Kub Ntxhov: Qhia txog qhov kub thiab txias hauv cov txheej txheem PCR, ua rau tsis sib haum xeeb ntawm mutant primers thiab cov qauv tsiaj qus, yog li txo qis hom tsiaj qus tom qab thiab txhim kho kev daws teeb meem.
• High Sensitivity: Muaj tseeb kuaj pom tsawg li 1% mutant DNA.
• Qhov raug zoo heev: Siv cov qauv sab hauv thiab UNG enzyme los tiv thaiv cov txiaj ntsig tsis zoo thiab tsis zoo.
• Yooj yim thiab nrawm: Ua tiav qhov kev sim hauv kwv yees li 120 feeb, siv ob lub raj tshuaj tiv thaiv los pab txhawm rau txheeb xyuas yim qhov kev hloov pauv txawv, ua tiav lub hom phiaj thiab cov txiaj ntsig txhim khu kev qha.
• Instrument Compatibility: Adapts rau ntau yam khoom siv PCR.

Precision tshuaj nyob rau hauv mob qog nqaij hlav hauv plab pib nrog kev kuaj pom tseeb molecular. Los ntawm kev siv peb cov KRAS Mutation Detection Kit, koj lub chaw kuaj mob tuaj yeem xa cov txiaj ntsig zoo, ua tau zoo uas ncaj qha rau tus neeg mob txoj kev kho mob.

Txhawb nqa koj lub chaw kuaj mob nrog kev txhim khu kev qha, kev siv thev naus laus zis - thiab ua kom muaj kev saib xyuas tus kheej tiag tiag.

Tiv tauj peb: marketing@mmtest.Com

Kawm paub ntxiv txog kev sib koom ua ke cov kev daws teeb meem no rau hauv koj qhov kev kuaj mob ua haujlwm.

#Colorectal #Cancer #DNA #Mutation #Precision #Targeted #Treatment #Cancer

Unlocking Precision Tshuaj nyob rau hauv mob qog noj ntshav

https://www.linkedin.com/posts/macro-micro-ivd_colorectal-cancer-dna-activity-7378358145812930560-X4MN?utm_source=share&utm_medium=member_desktop&rcm=ACoAADjGw3MB2kpoYpE3