Tshuaj Aspirin Kev Nyab Xeeb

Aspirin, raws li cov tshuaj tiv thaiv platelet aggregation zoo, yog siv dav hauv kev tiv thaiv thiab kho cov kab mob plawv thiab cerebrovascular.Cov kev tshawb fawb pom tias qee cov neeg mob tau pom tias tsis tuaj yeem cuam tshuam cov kev ua ntawm platelets txawm tias siv cov tshuaj aspirin ntev ntev, uas yog, tshuaj aspirin resistance (AR). Tus nqi yog kwv yees li 50% -60%, thiab muaj qhov sib txawv ntawm haiv neeg. Glycoprotein IIb/IIIa (GPI IIb/IIIa) plays lub luag haujlwm tseem ceeb hauv platelet aggregation thiab mob thrombosis ntawm qhov chaw ntawm vascular raug mob. Cov kev tshawb fawb tau pom tias cov noob polymorphisms ua lub luag haujlwm tseem ceeb hauv cov tshuaj aspirin tsis kam, feem ntau tsom rau GPIIIa P1A1 / A2, PEAR1 thiab PTGS1 gene polymorphisms. GPIIIa P1A2 yog cov noob tseem ceeb rau cov tshuaj aspirin. Kev hloov pauv hauv cov noob no hloov cov qauv ntawm GPIIb / IIIa receptors, ua rau kev sib txuas ntawm cov platelets thiab platelet aggregation. Txoj kev tshawb nrhiav pom tias qhov zaus ntawm P1A2 alleles hauv cov neeg mob aspirin-resistant muaj ntau dua li cov neeg mob aspirin-rhiab heev, thiab cov neeg mob P1A2 / A2 homozygous hloov pauv tau ua haujlwm tsis zoo tom qab noj tshuaj aspirin. Cov neeg mob uas hloov pauv P1A2 alleles nyob rau hauv stenting muaj qhov tshwm sim subacute thrombotic tus nqi uas yog tsib npaug ntawm P1A1 homozygous cov neeg mob homozygous, xav tau ntau dua ntawm cov tshuaj aspirin kom ua tiav cov nyhuv anticoagulant. PEAR1 GG allele teb zoo rau cov tshuaj aspirin, thiab cov neeg mob uas muaj AA lossis AG genotype uas noj cov tshuaj aspirin (los yog ua ke nrog clopidogrel) tom qab stent implantation muaj myocardial infarction thiab kev tuag. PTGS1 GG genotype muaj kev pheej hmoo siab ntawm cov tshuaj aspirin tsis kam (HR: 10) thiab muaj cov xwm txheej ntawm cov hlab plawv (HR: 2.55). AG genotype muaj qhov pheej hmoo me me, thiab yuav tsum tau ua tib zoo saib xyuas cov txiaj ntsig ntawm kev kho mob aspirin. AA genotype yog rhiab heev rau cov tshuaj aspirin, thiab qhov tshwm sim ntawm cov kab mob plawv kuj tsawg. Cov txiaj ntsig tshawb pom ntawm cov khoom no tsuas yog sawv cev rau kev tshawb pom ntawm tib neeg PEAR1, PTGS1, thiab GPIIIa noob.