Kev Nyab Xeeb ntawm Tshuaj Aspirin

Aspirin, ua ib yam tshuaj zoo tiv thaiv cov platelet aggregation, yog siv dav hauv kev tiv thaiv thiab kho cov kab mob plawv thiab cerebrovascular. Kev tshawb fawb pom tias qee tus neeg mob tau pom tias tsis muaj peev xwm tiv thaiv cov platelets ua haujlwm tau zoo txawm tias siv tshuaj aspirin tsawg tsawg ntev, uas yog, aspirin tsis kam (AR). Tus nqi yog li 50% -60%, thiab muaj qhov sib txawv ntawm haiv neeg. Glycoprotein IIb/IIIa (GPI IIb/IIIa) ua lub luag haujlwm tseem ceeb hauv platelet aggregation thiab thrombosis mob hnyav ntawm qhov chaw raug mob ntawm cov hlab ntsha. Kev tshawb fawb tau qhia tias cov noob caj noob ces polymorphisms ua lub luag haujlwm tseem ceeb hauv kev tsis kam aspirin, feem ntau tsom mus rau GPIIIa P1A1/A2, PEAR1 thiab PTGS1 noob caj noob ces polymorphisms. GPIIIa P1A2 yog lub noob caj noob ces tseem ceeb rau kev tsis kam aspirin. Kev hloov pauv hauv cov noob caj noob ces no hloov cov qauv ntawm GPIIb/IIIa receptors, ua rau muaj kev sib txuas ntawm cov platelets thiab platelet aggregation. Cov kev tshawb fawb pom tau tias qhov zaus ntawm P1A2 alleles hauv cov neeg mob uas tsis kam siv tshuaj aspirin yog siab dua li cov neeg mob uas tsis kam siv tshuaj aspirin, thiab cov neeg mob uas muaj P1A2/A2 homozygous mutations muaj qhov ua tau zoo tsis zoo tom qab noj tshuaj aspirin. Cov neeg mob uas mutant P1A2 alleles uas tau stenting muaj qhov tshwm sim subacute thrombotic uas yog tsib npaug ntawm cov neeg mob P1A1 homozygous wild-type, xav tau cov tshuaj aspirin ntau dua kom ua tiav cov teebmeem anticoagulant. Cov allele PEAR1 GG teb tau zoo rau aspirin, thiab cov neeg mob uas muaj AA lossis AG genotype uas noj aspirin (lossis ua ke nrog clopidogrel) tom qab stent implantation muaj myocardial infarction thiab kev tuag siab. Cov genotype PTGS1 GG muaj kev pheej hmoo siab ntawm kev tsis kam siv tshuaj aspirin (HR: 10) thiab muaj ntau qhov xwm txheej ntawm cov xwm txheej plawv (HR: 2.55). Cov genotype AG muaj kev pheej hmoo nruab nrab, thiab yuav tsum tau ua tib zoo saib xyuas cov txiaj ntsig ntawm kev kho mob aspirin. Cov genotype AA muaj kev cuam tshuam ntau dua rau aspirin, thiab qhov tshwm sim ntawm cov xwm txheej plawv yog qhov tsawg. Cov txiaj ntsig ntawm kev kuaj pom ntawm cov khoom no tsuas yog sawv cev rau cov txiaj ntsig ntawm kev kuaj pom ntawm tib neeg PEAR1, PTGS1, thiab GPIIIa noob.