Tib neeg BCR-ABL Fusion Gene Mutation

Lus piav qhia luv luv:

Cov khoom siv no tsim nyog rau kev kuaj pom zoo ntawm p190, p210 thiab p230 isoforms ntawm BCR-ABL fusion gene hauv tib neeg cov pob txha pob txha.


Product Detail

Khoom cim npe

Khoom npe

HWTS-GE010A-Human BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)

Kab mob sib kis

Chronic myelogenousleukemia (CML) yog ib hom kab mob qog nqaij hlav ntawm hematopoietic qia hlwb.Ntau tshaj 95% ntawm CML cov neeg mob nqa Philadelphia chromosome (Ph) hauv lawv cov qe ntshav.Predominant pathogenesis ntawm CML yog raws li hauv qab no: BCR-ABL fusion noob yog tsim los ntawm kev hloov pauv ntawm abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ntawm caj npab ntev ntawm chromosome 9 (9q34) thiab thaj tsam breakpoint pawg ( BCR) noob ntawm caj npab ntev ntawm chromosome 22 (22q11);fusion protein encoded los ntawm cov noob no muaj tyrosine kinase (TK) kev ua, thiab ua kom nws txoj hauv kev qis qis (xws li RAS, PI3K, thiab JAK/STAT) los txhawb kev faib cell thiab inhibit cell apoptosis, ua rau cov hlwb proliferate malignantly, thiab yog li ua rau. qhov tshwm sim ntawm CML.BCR-ABL yog ib qho tseem ceeb ntawm kev kuaj mob ntawm CML.Qhov kev hloov pauv hloov ntawm nws cov ntawv sau tseg yog qhov qhia tau zoo rau kev txiav txim siab ntawm leukemia thiab tuaj yeem siv los kwv yees qhov rov tshwm sim ntawm leukemia tom qab kho.

Channel

FAM BCR-ABL fusion noob
VIC/HEX Internal Control

Technical Parameters

Cia Ua kua: ≤-18 ℃ Hauv tsaus
Txee lub neej Kua: 9 lub hlis
Hom Qauv Cov qog nqaij hlav
LoD 1000 Daim / mL

Qhov tshwj xeeb

 

Tsis muaj kev sib cuam tshuam nrog lwm cov noob fusion TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, thiab PML-RARa
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  • Tom ntej:

  • Sau koj cov lus ntawm no thiab xa tuaj rau peb