Kev Hloov Pauv ntawm Tib Neeg BCR-ABL Fusion Gene
Lub npe khoom
HWTS-GE010A-Tib Neeg BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
HWTS-GE016A-Khoov Qhuav Tib Neeg BCR-ABL Fusion Gene Mutation Detection Kit (Fluorescence PCR)
Kev Tshawb Fawb Txog Kab Mob Sib Kis
Kab mob ntshav dawb myelogenous (CML) yog ib yam kab mob phem uas tshwm sim los ntawm cov qe ntshav dawb hematopoietic stem cells. Ntau tshaj 95% ntawm cov neeg mob CML muaj Philadelphia chromosome (Ph) nyob rau hauv lawv cov qe ntshav. Qhov ua rau mob CML yog raws li nram no: BCR-ABL fusion gene yog tsim los ntawm kev hloov chaw ntawm abl proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ntawm caj npab ntev ntawm chromosome 9 (9q34) thiab breakpoint cluster region (BCR) gene ntawm caj npab ntev ntawm chromosome 22 (22q11); cov fusion protein uas encoded los ntawm cov gene no muaj tyrosine kinase (TK) activity, thiab ua kom nws cov downstream signaling pathways (xws li RAS, PI3K, thiab JAK/STAT) ua haujlwm los txhawb kev faib cell thiab tiv thaiv cell apoptosis, ua rau cell loj hlob sai, thiab ua rau muaj CML. BCR-ABL yog ib qho ntawm cov cim qhia tseem ceeb ntawm CML. Qhov kev hloov pauv ntawm nws cov ntawv sau yog qhov qhia tau zoo rau kev txiav txim siab txog kev kwv yees ntawm leukemia thiab siv tau los kwv yees qhov rov tshwm sim ntawm leukemia tom qab kev kho mob.
Channel
| FAM | BCR-ABL fusion gene |
| VIC/HEX | Kev Tswj Xyuas Sab Hauv |
Cov Kev Ntsuas Kev Txawj
| Kev Khaws Cia | Kua: ≤-18 ℃ Hauv qhov tsaus ntuj |
| Lub sijhawm khaws cia | Kua: 9 lub hlis |
| Hom Qauv | Cov qauv pob txha |
| LoD | 1000 Daim Ntawv Luam / mL |
| Kev Tshwj Xeeb
| Tsis muaj kev sib tshuam nrog lwm cov noob sib xyaw TEL-AML1, E2A-PBX1, MLL-AF4, AML1-ETO, thiab PML-RARa. |
| Cov Cuab Yeej Siv Tau | Applied Biosystems 7500 Cov Txheej Txheem PCR Tiag-Lub Sijhawm Applied Biosystems 7500 Cov Txheej Txheem PCR Ceev Ceev Cov Txheej Txheem PCR QuantStudio® 5 Real-Time SLAN-96P Cov Txheej Txheem PCR Real-Time Lub tshuab LightCycler®480 Real-Time PCR LineGene 9600 Plus Real-Time PCR Detection System MA-6000 Lub Tshuab Thermal Cycler Uas Siv Tau Tiag Tiag BioRad CFX96 Lub Tshuab PCR Tiag-Lub Sijhawm BioRad CFX Opus 96 Lub Tshuab PCR Tiag-Lub Sijhawm |
