Tib neeg CYP2C19 Gene Polymorphism

CYP2C19 yog ib qho ntawm cov enzymes metabolizing tshuaj tseem ceeb hauv tsev neeg CYP450. Ntau cov substrates endogenous thiab kwv yees li 2% ntawm cov tshuaj kho mob raug metabolized los ntawm CYP2C19, xws li kev metabolism ntawm cov tshuaj antiplatelet aggregation inhibitors (xws li clopidogrel), proton twj tso kua mis inhibitors (omeprazole), anticonvulsants, thiab lwm yam. CYP2C19 gene polymorphisms kuj muaj qhov sib txawv hauv kev muaj peev xwm metabolizing ntawm cov tshuaj cuam tshuam. Cov kev hloov pauv no ntawm *2 (rs4244285) thiab *3 (rs4986893) ua rau poob ntawm cov haujlwm enzyme encoded los ntawm CYP2C19 gene thiab qhov tsis muaj zog ntawm cov peev xwm metabolic substrate, thiab ua rau cov ntshav concentration, yog li ua rau muaj kev tsis haum tshuaj cuam tshuam nrog cov ntshav concentration. *17 (rs12248560) tuaj yeem ua rau cov haujlwm enzyme encoded los ntawm CYP2C19 gene, kev tsim cov metabolites nquag, thiab txhim kho kev txwv tsis pub platelet aggregation thiab ua rau muaj kev pheej hmoo los ntshav. Rau cov neeg uas lub cev zom tshuaj qeeb, kev noj cov tshuaj ib txwm ntev yuav ua rau muaj kev phiv loj heev thiab cov kev mob tshwm sim: feem ntau yog ua rau lub siab puas, ua rau lub cev hematopoietic puas, ua rau lub paj hlwb hauv nruab nrab puas, thiab lwm yam, uas tuaj yeem ua rau tuag taus hauv cov xwm txheej hnyav. Raws li qhov sib txawv ntawm cov tshuaj metabolism, feem ntau muab faib ua plaub hom, uas yog ultra-fast metabolism (UM, *17/*17, *1/*17), fast metabolism (RM, *1/*1), intermediate metabolism (IM, *1/*2, *1/*3), slow metabolism (PM, *2/*2, *2/*3, *3/*3).