Tib neeg CYP2C9 thiab VKORC1 Gene Polymorphism

Lus piav qhia luv luv:

Cov khoom siv no siv tau rau hauv vitro qualitative nrhiav pom ntawm polymorphism ntawm CYP2C9 * 3 (rs1057910, 1075A>C) thiab VKORC1 (rs9923231, -1639G>A) hauv genomic DNA ntawm tib neeg cov ntshav kuaj.


Product Detail

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HWTS-GE014A-Human CYP2C9 thiab VKORC1 Gene Polymorphism Detection Kit (Fluorescence PCR)

Daim ntawv pov thawj

CE / TSO

Kab mob sib kis

Warfarin yog ib qho tshuaj tiv thaiv kab mob hauv qhov ncauj uas feem ntau siv hauv kev kho mob tam sim no, uas yog tsim los rau kev tiv thaiv thiab kho cov kab mob thromboembolic.Txawm li cas los xij, warfarin muaj qhov kev kho mob tsawg thiab sib txawv ntawm ntau haiv neeg thiab tib neeg.Kev txheeb xyuas tau qhia tias qhov sib txawv ntawm cov koob tshuaj ruaj khov hauv cov tib neeg sib txawv tuaj yeem ua tau ntau dua 20 npaug.Qhov tshwm sim tsis zoo los ntshav tshwm sim hauv 15.2% ntawm cov neeg mob noj tshuaj warfarin txhua xyoo, ntawm 3.5% tsim los ntshav tuag.Cov kev tshawb fawb Pharmacogenomic tau pom tias genetic polymorphism ntawm lub hom phiaj enzyme VKORC1 thiab metabolic enzyme CYP2C9 ntawm warfarin yog ib qho tseem ceeb cuam tshuam rau qhov sib txawv ntawm koob tshuaj warfarin.Warfarin yog ib qho tshwj xeeb inhibitor ntawm vitamin K epoxide reductase (VKORC1), thiab yog li inhibits clotting factor synthesis uas muaj vitamin K thiab muab anticoagulation.Ntau cov kev tshawb fawb tau qhia tias cov noob polymorphism ntawm VKORC1 tus txhawb nqa yog qhov tseem ceeb tshaj plaws cuam tshuam rau haiv neeg thiab tus kheej sib txawv ntawm qhov xav tau ntawm koob tshuaj warfarin.Warfarin yog metabolized los ntawm CYP2C9, thiab nws cov mutants qeeb qeeb metabolism ntawm warfarin.Cov tib neeg uas siv warfarin muaj kev pheej hmoo siab dua (ob zaug mus rau peb zaug ntau dua) los ntshav thaum ntxov ntawm kev siv.

Channel

FAM VKORC1 (-1639G>A)
CY 5 CYP2C9*3
VIC/HEX IC

Technical Parameters

Cia Ua kua: ≤-18 ℃
Txee lub neej 12 hli
Hom Qauv Fresh EDTA anticoagulated ntshav
CV ≤ 5.0%
LoD 1.0 ng / μL
Qhov tshwj xeeb Tsis muaj qhov cuam tshuam nrog lwm cov kab ke sib luag ntawm tib neeg genome (tib neeg CYP2C19 noob, tib neeg RPN2 noob);Kev hloov pauv ntawm CYP2C9 * 13 thiab VKORC1 (3730G> A) sab nraum qhov kev tshawb pom ntawm cov khoom siv no
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Ua hauj lwm Flow

Pom zoo extraction reagent: Macro & Micro-Test Viral DNA / RNA Kit (HWTS-3001, HWTS-3004-32, HWTS-3004-48, HWTS-3004-96) thiab Macro & Micro-Test Automatic Nucleic Acid Extractor (HWTS- 3006).


  • Yav dhau los:
  • Tom ntej:

  • Sau koj cov lus ntawm no thiab xa tuaj rau peb