Tib neeg EGFR GENE 29

Lub ntsws Cancer tau dhau los ua tus ua rau mob cancer tuag thoob ntiaj teb, tib neeg hem kev noj qab haus huv. Tsis yog-me me cell plab cancer rau li 80% ntawm cov neeg mob ntsws cancer. Piv txwv li tam sim no yog qhov tseem ceeb tshaj plaws molecular lub hom phiaj rau kev kho mob tsis-mob cancer me me cancer. Cov phosphorlation ntawm EGFR tuaj yeem txhawb kev qog ntshav kev loj hlob, sib txawv, kev tiv thaiv, anti- Apoptosis, thiab txhawb cov qog angiogenesis. EGFr Tyrosine Kinase Inhibitors (TKA) tuaj yeem thaiv cov lus qhia txog kev nkag rau cov qog ntawm cov qog, thiab muaj kev cuam tshuam rau cov qog nqaij hlav. Coob tus ntawm cov kev tshawb fawb tau pom tias cov tshuaj kho tau zoo ntawm EGFR-TIK yog ze rau cov xwm txheej ntawm cov qog ntshav nrog EGRF Gene sib hloov. EGRF caj ces nyob ntawm caj npab luv luv ntawm chromosome 7 (7p12), nrog rau tag nrho ntev ntawm 200kb thiab muaj 28 tug exons. Thaj av mutated feem ntau yog nyob hauv cov neeg tawm 18 txog 21, codons 746 txog li 45% thiab L858R kev sib hloov ntawm Exon 21% rau 45%. NCCN cov lus qhia rau kev kuaj mob thiab kho mob pob txha pob txha me me kom pom tseeb tias EGRF cov kev sim ua ntej EGPR-TKI tswj. Cov khoom siv ntsuas no yog siv los coj cov thawj coj ntawm kev txhim kho kev loj hlob ntawm cov neeg mob tus kheej rau cov neeg mob ntsws cell. Cov khoom siv no tsuas yog siv rau kev kuaj pom ntawm cov kev sib hloov pauv ntawm EGFR cov neeg mob cancer tsis yog mob cancer me me. Cov kev sim ntsuas yog rau kev kuaj mob siv xwb thiab yuav tsum tsis txhob siv los ua ib qho kev kho mob rau tus kheej. Cov kws kho mob yuav tsum xav txog tus neeg mob, kev qhia yeeb tshuaj, thiab kho cov tshuaj tiv thaiv thiab lwm yam kev sim ua haujlwm rau kev txiav txim siab.