Tib neeg EGFR Gene 29 Mutations
Khoom npe
HWTS-TM001A-Human EGFR Gene 29 Mutations Detection Kit (Fluorescence PCR)
Kab mob sib kis
Mob ntsws cancer tau dhau los ua qhov ua rau mob qog noj ntshav thoob ntiaj teb, ua rau tib neeg kev noj qab haus huv hnyav.Cov qog nqaij hlav qog nqaij hlav tsis yog me me suav txog li 80% ntawm cov neeg mob qog noj ntshav.EGFR tam sim no yog lub hom phiaj tseem ceeb tshaj plaws rau kev kho mob qog noj ntshav ntawm lub ntsws uas tsis yog me me.Cov phosphorylation ntawm EGFR tuaj yeem txhawb cov qog cell loj hlob, sib txawv, ntxeem tau, metastasis, tiv thaiv apoptosis, thiab txhawb cov qog angiogenesis.EGFR tyrosine kinase inhibitors (TKI) tuaj yeem thaiv EGFR teeb liab txoj hauv kev los ntawm inhibiting EGFR autophosphorylation, yog li inhibiting kev loj hlob thiab sib txawv ntawm cov qog hlwb, txhawb cov qog cell apoptosis, txo cov qog angiogenesis, thiab lwm yam, thiaj li ua tiav cov kev kho mob qog nqaij hlav.Ntau cov kev tshawb fawb tau pom tias qhov kev kho mob ntawm EGFR-TKI muaj feem cuam tshuam nrog cov xwm txheej ntawm EGFR noob hloov, thiab tuaj yeem cuam tshuam kev loj hlob ntawm cov qog hlwb nrog EGFR noob hloov.EGFR noob nyob rau ntawm caj npab luv ntawm chromosome 7 (7p12), nrog rau tag nrho ntev ntawm 200Kb thiab muaj 28 exons.Lub cheeb tsam mutated feem ntau yog nyob rau hauv exons 18 txog 21, codons 746 txog 753 deletion mutation ntawm exon 19 suav txog li 45% thiab L858R hloov pauv ntawm exon 21 suav txog li 40% txog 45%.NCCN Cov Lus Qhia rau Kev Ntsuam Xyuas thiab Kev Kho Mob ntawm Cov Mob Tsis Zoo ntawm Lub ntsws me me qhia meej tias EGFR noob hloov pauv yuav tsum tau ua ua ntej EGFR-TKI kev tswj hwm.Cov khoom siv kuaj no yog siv los coj kev tswj hwm ntawm epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) cov tshuaj, thiab muab lub hauv paus rau tus kheej cov tshuaj rau cov neeg mob uas tsis yog mob qog noj ntshav me me.Cov khoom siv no tsuas yog siv rau kev tshawb nrhiav kev hloov pauv hauv EGFR noob hauv cov neeg mob uas tsis yog mob qog noj ntshav me me.Cov txiaj ntsig kev xeem no tsuas yog siv rau kev kho mob nkaus xwb thiab yuav tsum tsis txhob siv los ua ib lub hauv paus rau kev kho tus kheej ntawm cov neeg mob.Cov kws kho mob yuav tsum xav txog tus neeg mob tus mob, kev qhia tshuaj, thiab kev kho mob Cov tshuaj tiv thaiv thiab lwm yam kev ntsuas ntsuas thiab lwm yam yog siv los txiav txim siab cov txiaj ntsig kev xeem.
Channel
| FAM | IC Reaction Buffer, L858R Reaction Buffer, 19del Reaction Buffer, T790M Reaction Buffer, G719X Reaction Buffer, 3Ins20 Reaction Buffer, L861Q Reaction Buffer, S768I Reaction Buffer |
Technical Parameters
| Cia | Ua kua: ≤-18 ℃ Hauv qhov tsaus ntuj;Lyophilized: ≤30 ℃ Hauv qhov tsaus ntuj |
| Txee lub neej | Kua: 9 lub hlis;Lyophilized: 12 lub hlis |
| Hom Qauv | cov qog nqaij hlav tshiab, khov kho kab mob, ntu paraffin-embedded pathological cov ntaub so ntswg los yog seem, ntshav lossis ntshav |
| CV | 5.0% |
| LoD | nucleic acid tshuaj tiv thaiv kev tshawb nrhiav nyob rau hauv keeb kwm yav dhau ntawm 3ng / μL hom tsiaj qus, tuaj yeem txheeb xyuas 1% kev hloov pauv |
| Qhov tshwj xeeb | Tsis muaj qhov cuam tshuam nrog cov tsiaj qus-hom tib neeg genomic DNA thiab lwm hom mutant |
| Cov cuab yeej siv tau | Siv Biosystems 7500 Real-Time PCR SystemsSiv Biosystems 7300 Real-Time PCR Systems QuantStudio® 5 Real-Time PCR Systems LightCycler® 480 Real-Time PCR system BioRad CFX96 Real-Time PCR System |
Ua hauj lwm Flow
