Tib Neeg Ros1 Fusion Gene Gene

Ros1 yog lub transmembrane Tyrosine Kinase ntawm cov tswj hwm Insulin insulor. Ros1 fusion gene tau lees paub tias yog lwm tus tseem ceeb tsis yog cov gene tsav cancer me me cancer. Raws li ib tug sawv cev ntawm tus tshiab tshwj xeeb moleecular subtype, qhov tshwm sim ntawm Ros1 fusion gene hauv NSONEST GENEES hauv NSONESES QIS 32, 35 thiab Fused nrog Genes xws li CD74, Ezr, SLC34A2, thiab SDC4, nws tseem yuav ua kom Ros1 Tyrosine Kinase cheeb tsam. Kev ua haujlwm txawv txav Ros1 Kinase tuaj yeem ua kom qis dua txoj hauv kev xws li Ras / Mapk / AkT3, thiab stat3, thiab stat3, yog li ntawm cov qog nqaij hlav, thiab metastasis ntawm cov qog nqaij hlav, thiab ua rau mob qog nqaij hlav. Ntawm Ros1 fusion hloov, cd74-Ros1 cov nyiaj tau rau kwv yees li ntawm 152%, SLC34A2 nyiaj rau txog li ntawm 12%, thiab SDC4 cov nyiaj rau li ntawm 7%. Cov kev tshawb fawb tau pom tias ATP-khi qhov chaw ntawm catalytic domain ntawm Alk Tyrosine Kinase me me molecuentitoring cov molotitor crizotinib thiab yog li muaj cov txiaj ntsig pom tseeb Nyob rau hauv kev kho mob ntawm NSCLC nrog FUSION MUAB NTAWM ROS1. Yog li, nrhiav tau ntawm Ros1 fusion hloov yog lub hauv paus thiab hauv paus rau kev coj ua kev siv cov ntaub ntawv crizotinib.