Kev Hloov Pauv KRAS 8

Cov kev hloov pauv tseem ceeb hauv cov noob caj noob ces KRAS tau pom muaj nyob rau hauv ntau hom qog nqaij hlav tib neeg, kwv yees li 17% ~ 25% kev hloov pauv hauv qog nqaij hlav, 15% ~ 30% kev hloov pauv hauv cov neeg mob qog nqaij hlav ntsws, 20% ~ 50% kev hloov pauv hauv cov neeg mob qog nqaij hlav plab hnyuv. Vim tias cov protein P21 uas tau encoded los ntawm cov noob caj noob ces K-ras nyob rau hauv qab ntawm txoj kev signaling EGFR, tom qab kev hloov pauv ntawm cov noob caj noob ces K-ras, txoj kev signaling downstream yeej ib txwm ua haujlwm thiab tsis cuam tshuam los ntawm cov tshuaj upstream targeted ntawm EGFR, ua rau muaj kev loj hlob ntawm cov hlwb malignant. Kev hloov pauv hauv cov noob caj noob ces K-ras feem ntau muab kev tiv thaiv rau EGFR tyrosine kinase inhibitors hauv cov neeg mob qog nqaij hlav ntsws thiab kev tiv thaiv rau cov tshuaj antibody tiv thaiv EGFR hauv cov neeg mob qog nqaij hlav plab hnyuv. Xyoo 2008, Lub Koom Haum Saib Xyuas Kab Mob Cancer Hauv Tebchaws (NCCN) tau tshaj tawm cov lus qhia txog kev kho mob rau mob qog noj ntshav hauv plab hnyuv, uas tau taw qhia tias cov chaw hloov pauv uas ua rau K-ras ua haujlwm feem ntau nyob hauv codons 12 thiab 13 ntawm exon 2, thiab pom zoo kom txhua tus neeg mob uas muaj mob qog noj ntshav hauv plab hnyuv metastatic tuaj yeem kuaj xyuas K-ras hloov pauv ua ntej kev kho mob. Yog li ntawd, kev kuaj pom sai thiab raug ntawm K-ras gene hloov pauv yog qhov tseem ceeb heev rau kev taw qhia tshuaj kho mob. Cov khoom siv no siv DNA ua cov qauv kuaj pom los muab kev ntsuam xyuas zoo ntawm qhov xwm txheej hloov pauv, uas tuaj yeem pab cov kws kho mob hauv kev tshuaj xyuas mob qog noj ntshav hauv plab hnyuv, mob qog noj ntshav ntsws thiab lwm tus neeg mob qog uas tau txais txiaj ntsig los ntawm cov tshuaj tsom. Cov txiaj ntsig ntawm kev xeem ntawm cov khoom siv yog rau kev siv hauv kev kho mob xwb thiab yuav tsum tsis txhob siv ua lub hauv paus rau kev kho mob tus kheej ntawm cov neeg mob. Cov kws kho mob yuav tsum txiav txim siab txog cov txiaj ntsig ntawm kev xeem raws li cov yam ntxwv xws li tus neeg mob tus mob, cov cim qhia tshuaj, kev teb rau kev kho mob thiab lwm yam cim qhia kev kuaj hauv chaw kuaj mob.