● Kab mob ntsws Mycobacterium
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Mycobacterium Tuberculosis Nucleic Acid thiab Rifampicin (RIF), Kev Tiv Thaiv (INH)
Cov khoom siv no yog siv rau kev kuaj pom Mycobacterium tuberculosis DNA hauv tib neeg cov hnoos qeev, cov khoom siv kho mob (LJ Medium) thiab cov kua kho mob (MGIT Medium), cov kua dej ntxuav ntsws, thiab cov kev hloov pauv hauv thaj tsam 507-533 amino acid codon (81bp, thaj tsam txiav txim siab qhov tsis kam ntawm rifampicin) ntawm rpoB gene ntawm Mycobacterium tuberculosis rifampicin, nrog rau cov kev hloov pauv hauv cov chaw hloov pauv tseem ceeb ntawm Mycobacterium tuberculosis isoniazid tsis kam. Nws muab kev pab rau kev kuaj mob Mycobacterium tuberculosis kab mob, thiab nws ntes cov noob tiv thaiv tseem ceeb ntawm rifampicin thiab isoniazid, uas pab nkag siab txog kev tiv thaiv tshuaj ntawm Mycobacterium tuberculosis uas tus neeg mob kis.
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Kev Hloov Pauv ntawm Mycobacterium Tuberculosis INH
Cov khoom siv no yog tsim rau kev kuaj pom qhov tseem ceeb ntawm cov qhov chaw hloov pauv tseem ceeb hauv cov qauv hnoos qeev tib neeg sau los ntawm cov neeg mob tubercle bacillus zoo uas ua rau mycobacterium tuberculosis INH: InhA promoter cheeb tsam -15C>T, -8T>A, -8T>C; AhpC promoter cheeb tsam -12C>T, -6G>A; homozygous mutation ntawm KatG 315 codon 315G>A, 315G>C.
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Mycobacterium Tuberculosis Rifampicin Tsis kam
Cov khoom siv no yog tsim rau kev kuaj pom zoo ntawm homozygous mutation hauv thaj tsam 507-533 amino acid codon ntawm rpoB gene uas ua rau Mycobacterium tuberculosis tsis kam rifampicin.
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Kev Tiv Thaiv Mycobacterium Tuberculosis Nucleic Acid thiab Rifampicin
Cov khoom siv no yog tsim rau kev kuaj pom zoo ntawm Mycobacterium tuberculosis DNA hauv cov qauv hnoos qeev tib neeg hauv vitro, nrog rau kev hloov pauv homozygous hauv thaj tsam 507-533 amino acid codon ntawm rpoB gene uas ua rau Mycobacterium tuberculosis tsis kam rifampicin.
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DNA ntawm Mycobacterium Tuberculosis
Nws yog qhov tsim nyog rau kev kuaj pom zoo ntawm Mycobacterium tuberculosis DNA hauv cov qauv hnoos qeev tib neeg, thiab nws yog qhov tsim nyog rau kev kuaj mob pab txhawb nqa ntawm Mycobacterium tuberculosis kab mob.
