Kev Tshawb Pom BCR-ABL Tseem Ceeb rau Kev Kho Mob CML

Kab mob ntshav dawb myelogenous (CML) yog ib yam kab mob phem uas tshwm sim los ntawm cov qe ntshav dawb hematopoietic stem cells. Ntau tshaj 95% ntawm cov neeg mob CML muaj Philadelphia chromosome (Ph) nyob hauv lawv cov qe ntshav. Thiab BCR-ABL fusion gene yog tsim los ntawm kev hloov chaw ntawm ABL proto-oncogene (Abelson murine leukemia viral oncogene homolog 1) ntawm caj npab ntev ntawm chromosome 9 (9q34) thiab breakpoint cluster region (BCR) gene ntawm caj npab ntev ntawm chromosome 22 (22q11). Nws cov fusion protein uas encoded los ntawm cov gene no muaj tyrosine kinase (TK) activity, thiab ua kom nws cov downstream signaling pathways (xws li RAS, PI3K, thiab JAK/STAT) ua haujlwm los txhawb kev faib cell thiab tiv thaiv cell apoptosis, ua rau cell loj hlob sai, thiab ua rau CML tshwm sim.

BCR-ABL fusion gene, uas yog qhov tseem ceeb hauv kev txhim kho CML, ua haujlwm ua lub cim tseem ceeb rau kev kuaj mob ntawm CML. Nws qhov kev kuaj pom pab saib xyuas tus neeg mob's teb rau tyrosine kinase inhibitors (TKIs) thiab kwv yees qhov rov tshwm sim ntawm leukemia, uas yog qhov tseem ceeb rau kev tswj hwm tus neeg mob CML zoo.

Tib Neeg BCR-ABLCov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Gene Fusionlos ntawm Macro & Micro-Test rau kev kuaj pom zoo ntawm BCR-ABL hauv cov neeg mob CML, pab kuaj mob CML thiab coj cov kev kho mob uas tsom mus rau kev kho mob los txhim kho cov tswv yim kho mob kom zoo rau kev tswj hwm tus neeg mob zoo. BCR-ABL fusion gene, uasyogtseem ceebhauv kev txhim kho CML,ua haujlwm ua tus cim tseem ceeb ntawm kev kuaj mobofCMLNws qhov kev kuaj pom pab tausaib xyuastus neeg mob'skev teb rau tyrosine kinase inhibitors (TKIs)thiabkwv yees qhov rov tshwm sim ntawm leukemia, uas yogtseem ceebto ua tau zooCMLkev tswj hwm tus neeg mob.

Cov Khoom Siv Tshawb Nrhiav Kev Hloov Pauv ntawm Tib Neeg BCR-ABL Fusion Gene los ntawm Macro & Micro-Test rau kev kuaj pom zoo ntawm BCR-ABL hauv cov neeg mob CML, pabCMLkev kuaj mobthiabcov neeg qhia kevkev kho mob uas tsom mus rau kev kho mobtoua kom zoo duaecov tswv yim kho mob rau kev tswj hwm tus neeg mob zoo.

Kev Paub TxogDkev ntsuam xyuas:Tib lub sijhawmkev kuaj pomrau3cov noob sib xyaw ua ke (P210, P190, P230)raukev pab them nqi dav dav thiabkev tiv thaiv ntawm cov rooj plaub uas tsis tau pom;

Kev rhiab heev:Cov kua dej kuaj pom cov noob sib xyawnrog LoDntawm 1000 daim / mL,thiab lub lyophilized versionof 500 daim/mL;

Zoo heevAqhov tseeb: Isab hauvkev tswj hwmthiab UNG enzyme los tiv thaiv cov kev kuaj mob cuav& cov negatives;

Kev Ua Haujlwm Yooj Yim thiab Kev Ua Haujlwm Zoo:Kev ua haujlwm kaw lub raj,tsis muaj cov khoomkev ua tiav tom qab,thiabkev kuaj pomnyob rau hauv60 feebraucov txiaj ntsig zoo thiab txhim khu kev qha;

Ntau ntxivCov kev xaiv：Cov kua thiab lyophilized versions rau cov neeg siv khoom xaiv;

Kev Sib Tw Dav Dav:Sib xws nrog feem ntau ntawm PCR systems rau kev nkag mus rau hauv chav kuaj dav dav.