CRUCIA BCR-ALL nrhiav kom txhij rau CML Kev Kho Mob

Mob Myelogenouslexemia (CML) yog tus kab mob malignant ntawm hematopoietic qia hlwb. Ntau tshaj 95% ntawm CML cov neeg mob nqa lub Philadelphia chromosome (Ph) hauv lawv cov ntshav hlwb. Thiab bcr-abl fusion gene tau tsim los ntawm ib qho kev sib txuas ntawm cov leeg ntawm chromosome 9 (9q34) thiab Breakpat pawg pawg (BRR) nyob sab caj npab ntev ntawm chromosome 22 (22q11). Nws fusion protein enreed los ntawm cov gene no muaj Tyrosine Kinase (xws li ras, pi3k, thiab ua kom cov cell proliferate malospifant, thiab yog li ua qhov tshwm sim ntawm cml.

BR-ABL FUSION Gene, uas yog qhov tseem ceeb hauv kev txhim kho CML, pabcuam ua tus cim kuaj mob tseem ceeb ntawm cml. Nws cov kev pom tau pab los saib xyuas tus neeg mob'S lus teb rau Tyrosine Kinase Inhibitors (TKIS) thiab kwv yees cov kab mob leukemia rov muaj dua, uas yog qhov tseem ceeb rau kev tswj hwm tus neeg mob CML.

Tib neeg BCR-ABLFusion Gene Mutation Nrhiav Khoom SivLos ntawm Macro & micro-xeem rau kev pom zoo ntawm BCR-ABL hauv CML hauv CML cov neeg mob, Pab CML Kev kuaj mob thiab cov lus qhia kev kho mob kho mob Txhawm rau ua kom zoo rau cov tswv yim kho rau cov neeg mob tswj hwm tus neeg mob thiab cov tub rog ua haujlwme, uasyogtseem ceebHauv kev txhim kho CML,ua hauj lwm ua tus cim tseem ceebofCmlCov. Nws cov lus pom tau pab rausaib xyuastus neeg muaj mob'sTeb rau Tyrosine Kinase Inhibitors (TKIS)thiabKwv yees li kev rov muaj dua, uas yogtseem ceebto ua tau rauCmlKev Tswj Tus Neeg Mob.

Tib Neeg BCR-ABL FUSION GENE GENE MENYUAM nrhiav khoom siv Los ntawm Macro & micro-xeem rau cov neeg mob BCR-ABL hauv CML cov neeg mob, PabCmlkev kuajthiabkhoom qhiaKev ua hom phiaj kho mobtokev zooeKho cov tswv yim rau cov kev tswj xyuas cov neeg mob.

Muaj txhij txhuaDthiab:Tib txhijkev pomrau3Cov Kev Fusion Genes (P210, P190, P230)rauKev tiv thaiv kom dav thiabkev tiv thaiv los ntawm cov teeb meem tsis tuaj;

High rhiab:Cov kua kem scen Ntes fusion noobnrog Lodntawm 1000 daim ntawv luam / ml,thiab Lub lyophilized versionof 500 daim / ml;

Zoo tshajACcuracy: Itus ntookev tswj hwmthiab ung enzyme los tiv thaiv cov cuav cuav&negatives;

Kev lag luam yooj yim thiab ua haujlwm tau zoo:Kev ua haujlwm kaw-raj,Dawb ntawm cov khoomKev Ua Si Tom Qab,thiabkev pomnyob hauv60 feebrauLub hom phiaj thiab cov txiaj ntsig txhim khu kev qha;

Ntau duaYam ua xoob:Kua thiab Lyophilized version rau cov neeg siv khoom;

Kev sib xws:Tau tshaj nrog cov tshuab PCR cov tshuab rau kev siv zog dav dav.