Tsis ntev los no,Tuam Tshoj CDC Txhua Lub Limtiamtau luam tawm ib tsab xov xwm tshawb fawb tseem ceeb uas piav qhia txog kev tshawb nrhiav txog kab mob thiab etiological ntawm kev sib kis kab mob gastroenteritis uas tshwm sim los ntawm Group C rotavirus (RVC) ntawm lub tsev kawm ntawv theem pib hauv Luzhou, Sichuan, thaum Lub Kaum Hli 2025. Qhov tseem ceeb, Macro & Micro-Test lub cuab yeej ntes kab mob siab (probe-capture) thiab cov thev naus laus zis txhim kho tag nrho genome tau ua lub luag haujlwm tseem ceeb hauv kev tshawb nrhiav. Los ntawm kev ua kom muaj kev txheeb xyuas kab mob raug thiab kev piav qhia txog genomic, cov thev naus laus zis tau muab cov pov thawj tseem ceeb rau kev lees paub qhov kev sib kis sai, kev nrhiav qhov chaw tseeb, thiab kev tswj hwm qhov kev sib kis zoo.
Kev Sib Kis Sai Sai: Thawj Qhov Kev Sib Kis RVC Tau Tshaj Tawm Hauv Sab Qab Teb Sab Hnub Poob Suav Teb
Thaum Lub Kaum Hli 15, 2025, muaj tus kab mob gastroenteritis kis thoob plaws hauv tsev kawm ntawv theem pib hauv Luzhou. Lub tsev kawm ntawv muaj tag nrho 1,943 tus tub ntxhais kawm thiab cov neeg ua haujlwm, nrog rau 32 tus neeg mob tau tshaj tawm, suav nrog 6 tus neeg tau kuaj pom tias muaj tus kab mob hauv chaw kuaj mob thiab 26 tus neeg mob uas tau kuaj pom tias muaj tus kab mob, ua rau muaj tus kab mob tag nrho ntawm 1.65%. Qhov kev kis tus kab mob tau nce siab tshaj plaws ntawm Lub Kaum Hli 15 thiab 16, nrog rau Qib 7, Qib 5 muaj tus kab mob siab tshaj plaws (23.08%). Cov neeg mob feem ntau yog cov menyuam kawm ntawv hnub nyoog (hnub nyoog nruab nrab: 10 xyoo), feem ntau yog ntuav (65.62%), raws plab (46.87%), thiab mob plab (37.50%). Cov tsos mob feem ntau kav ntev li 1-3 hnub, thiab txhua tus neeg mob tau zoo tsis muaj teeb meem loj.
Kev tshawb nrhiav txog kab mob sib kis tau pom tias tus neeg mob no yog ib tug tub hluas hnub nyoog 11 xyoos nyob rau hauv Chav Kawm 7, Qib 5. Nws tus muam yau tau muaj cov tsos mob zoo sib xws ua ntej nws, qhia tias kev kis tus kab mob hauv tsev neeg yog qhov pib. Kev tswj tsis tau zoo ntawm cov ntuav hauv tsev kawm ntawv - suav nrog kev ntxuav thiab pov tseg yam tsis tau tua kab mob lossis cais tawm hauv thaj chaw - ua ke nrog kev ntxuav tes tsis zoo ntawm cov tub ntxhais kawm, tej zaum yuav ua rau muaj kev kis ntxiv. Feem ntau cov chav kawm uas raug cuam tshuam nyob nruab nrab ntawm pem teb thib ob thiab thib tsib thiab sib koom chav dej txiv neej uas nyob ib sab, qhia tias ob qho tib si aerosol thiab kev sib kis tau los ntawm kev sib cuag tej zaum yuav ua rau muaj kev kis tus kab mob.
Qhov kev tshawb nrhiav tau dhau los ua qhov nyuaj tshwj xeeb vim tias kev kuaj mob tsis tu ncua, suav nrog kev kuaj mob norovirus thiab Group A rotavirus, tau muab cov txiaj ntsig tsis zoo, qhia tias muaj tus kab mob tsis tshua muaj tshwm sim.
Kev Kuaj Mob Etiological: Macro & Micro-Test's Whole-Genome Sequencing Txheeb Xyuas Tus Neeg Ua Phem
Kev kuaj thawj zaug rau norovirus tsis pom muaj dab tsi. Tom qab ntawd, Luzhou CDC tau siv kev sim PCR tiag tiag uas muaj peev xwm nrhiav tau 28 tus kab mob tib lub sijhawm, suav nrog 8 tus kab mob, 17 tus kab mob me me, thiab 3 tus kab mob me me, los tshuaj xyuas yim tus qauv kuaj mob. Thaum Lub Kaum Hli 17, rau tus qauv kuaj pom tias muaj tus kab mob rotavirus Pawg C, thiab tau txheeb xyuas tus kab mob ua rau muaj tus kab mob no.
Yuav kom nrhiav tau qhov chaw uas muaj tus kab mob sib kis ntxiv, cov kws tshawb nrhiav tau ua ob qho tib si nanopore metagenomic sequencing thiab Macro & Micro-Test's probe-capture whole-genome enrichment sequencing rau tsib tus qauv zoo. Txoj hauv kev no tau ua tiav tsib qhov RVC genome sequences tiav (SC01–SC05). Lub tswv yim sib xyaw ua ke ntawm kev tshuaj ntsuam multiplex PCR sai ua raws li kev daws teeb meem siab tag nrho-genome sequencing tau muab kev txhawb nqa zoo rau kev tshawb fawb txog kab mob molecular thiab kev nrhiav qhov chaw raug.
Kev Nkag Siab Txog Kev Tshawb Fawb: Kev Txheeb Xyuas Thawj Zaug ntawm M2 Genotype hauv Sab Qab Teb Hnub Poob Suav Teb
Raws li cov ntaub ntawv zoo tag nrho ntawm cov noob caj noob ces uas tau tsim los ntawm kev siv Macro & Micro-Test cov thev naus laus zis, pab pawg tshawb fawb tau tshaj tawm ntau qhov kev tshawb pom tseem ceeb hauv kev tshawb fawb:
Kev lees paub ntawm kev sib kis monoclonal:Tag nrho tsib tus kab mob sib kis tau sib koom ua ib qho genotype zoo ib yam (G4-P[2]-I2-R2-C2-M2-A2-N2-T2-E2-H2), nrog tsuas yog 0–1 qhov sib txawv ntawm nucleotide polymorphism (SNP), qhia meej tias qhov kev sib kis tau los ntawm ib txoj saw hlau sib kis.
Kev tshawb pom ntawm M2 genotype:Kev tshuaj xyuas phylogenetic qhia tau hais tias cov kab mob Luzhou RVC yog cov kab mob M2 genotype es tsis yog M3 genotype uas yav dhau los suav tias yog cov kab mob RVC Suav. Qhov kev tshawb pom no ua rau muaj kev tsis sib haum xeeb txog kev faib tawm ntawm RVC genotype hauv Suav teb thiab lees paub qhov tshwm sim ntawm M2 genotype hauv sab qab teb sab hnub poob Suav teb.
Cov pov thawj ntawm kev sib txuas lus thoob ntiaj teb:Kev sib piv tag nrho cov genome tau qhia txog kev zoo sib xws ntawm cov noob caj noob ces ntawm Luzhou thiab cov noob caj noob ces RVC uas tau tshaj tawm yav dhau los hauv Yunnan (2025), Novosibirsk, Russia (2017), thiab Ltalis (2012), qhia txog kev muaj nyob ntawm Eurasian kis tau tus kab mob.
Kev Cuam Tshuam rau Kev Tiv Thaiv thiab Kev Tswj: Kev Tshawb Pom Thaum Ntxov thiab Kev Pabcuam Sai yog Qhov Tseem Ceeb
Tom qab kuaj pom tus kab mob, Luzhou CDC tam sim ntawd tau siv cov kev tswj hwm tag nrho, suav nrog kev cais tus neeg mob, kev tua kab mob hauv ib puag ncig, kev tswj hwm ntuav raws li tus qauv, thiab kev ncua ib ntus ntawm pawg neeg mob. Kev sib kis tau ua tiav hauv ib lub sijhawm incubation, tsis muaj cov neeg mob ntxiv tau tshaj tawm tom qab 21 Lub Kaum Hli.
Qhov kev tshawb nrhiav kuj muab ib zaj lus qhia tseem ceeb rau kev noj qab haus huv pej xeem: rau cov kab mob gastroenteritis uas kuaj tsis pom muaj kab mob Group A rotavirus thiab norovirus, kab mob Group C rotavirus thiab lwm yam kab mob rotavirus uas tsis yog Group A yuav tsum tau suav nrog rau hauv kev kuaj mob niaj hnub.
Daim kev tshawb fawb no sawv cev rau thawj qhov kev sib kis kab mob rotavirus Group C hauv sab qab teb sab hnub poob Suav teb thiab thawj qhov kev txheeb xyuas ntawm M2 genotype hauv thaj av, nthuav dav kev nkag siab tam sim no ntawm RVC epidemiology hauv East Asia. Hauv kev tshawb nrhiav no, Macro & Micro-Test qhov kev daws teeb meem sib xyaw ua ke ntawm kev tshuaj ntsuam multiplex PCR nrog rau kev txheeb xyuas tag nrho cov genome enrichment sequencing tau ua pov thawj tias muaj txiaj ntsig zoo los ntawm kev ua kom muaj kev txheeb xyuas cov kab mob sai thiab kev nrhiav qhov chaw molecular siab, muab cov txheej txheem kev siv tshuab rov ua dua rau kev tshawb nrhiav thiab tswj cov kab mob sib kis yav tom ntej.
Lub sijhawm tshaj tawm: Lub Xya Hli-30-2026