PCT/IL-6 ua ke

PCT yog lub hauv paus ntawm calcitonin, uas yog glycoprotein tsim los ntawm 116 amino acids.Tus nqi molecular yog li 12.8kd.Nws tsis muaj kev ua haujlwm hormonal.Raws li lub cev muaj zog, PCT feem ntau yog tsim los ntawm cov thyroid C hlwb.Thaum kis kab mob, macrophages thiab monocytes nyob rau hauv daim siab, lymphocytes thiab endocrine hlwb nyob rau hauv lub ntsws thiab plab hnyuv cov ntaub so ntswg synthesize thiab secrete ib tug loj npaum li cas ntawm PCT nyob rau hauv qhov kev txiav txim ntawm endotoxin, qog necrosis factor-α thiab interleukin-6, ua rau ib tug tseem ceeb nce. hauv cov ntshav PCT qib.
Interleukin-6 yog ib qho cytokine qhia los ntawm lub cev tiv thaiv kab mob thaum pib raug mob thiab kis kab mob.Nws yog tsim los ntawm fibroblasts, monocytes / macrophages, T lymphocytes, B lymphocytes, epithelial hlwb, keratinocytes, thiab ntau yam qog hlwb.IL-6 yog tsim los ntawm ob glycoprotein chains, ib tug yog ib tug α saw nrog ib tug molecular hnyav ntawm 80kd;Lwm qhov yog β saw nrog qhov hnyav ntawm molecular ntawm 130kd [5].Yog tias tib neeg lub cev raug txhawb los ntawm kev mob, IL-6 qib nce nrawm, uas ua rau muaj kev sib haum xeeb rau theem mob hnyav ntawm lub siab thiab txhawb kev tsim cov protein ntau xws li C-reactive protein (CRP) thiab serum amyloid A (SAA). ).Yog li ntawd, IL-6 yog tus cim ntxov tshaj plaws kom nce thaum muaj mob tshwm sim.